Efudex and B12 drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Efudex (fluorouracil) and B12 (cobalamin). Common drug interactions include alopecia among females and basal cell carcinoma among males.

The phase IV clinical study analyzes what interactions people have when they take Efudex and B12. It is created by eHealthMe based on reports of 51 people who take the same drugs from the FDA, and is updated regularly.

What is Efudex?

Efudex has active ingredients of fluorouracil. It is often used in actinic keratosis. eHealthMe is studying from 1,391 Efudex users. Check the latest studies of Efudex.

What is B12?

B12 has active ingredients of cobalamin. It is often used in vitamin b12 deficiency. eHealthMe is studying from 121,894 B12 users. Check the latest studies of B12.

On Jul, 19, 2026

51 people who take Efudex and B12 together, and have interactions are studied.

What are the common drug interactions of Efudex and B12, by gender? *:

female:

Alopecia (absence of hair from areas of the body)
Blood creatine increased
Dehydration (dryness resulting from the removal of water)
Hair colour changes
Hair disorder
Drug hypersensitivity
Impulsive behaviour
Suicidal ideation
Suicide attempt
Asthenia (weakness)

male:

Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Rash pruritic (redness with itching)
Squamous cell carcinoma (a cancer of a kind of epithelial cell)
Myositis (inflammation of the muscles)
Rash
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Alanine aminotransferase increased
Animal scratch
Anxiety

What are the common drug interactions of Efudex and B12, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Alopecia (absence of hair from areas of the body)
Hair colour changes
Hair disorder
Citrobacter infection (infection by citrobacter (bacteria))
Urinary tract infection bacterial

50-59:

Alopecia (absence of hair from areas of the body)
Drug hypersensitivity
Hair colour changes
Hair disorder
Impulsive behaviour
Suicidal ideation
Suicide attempt
Decreased appetite
Diarrhoea
Injection site pain

60+:

Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Dehydration (dryness resulting from the removal of water)
Pancreatic carcinoma (pancreatic cancer)
Myositis (inflammation of the muscles)
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Supraventricular tachycardia (rapid heart rhythm originating at or above the atrioventricular node)
Visual impairment
Alanine aminotransferase increased
Anxiety
Aspartate aminotransferase increased

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 8 people, 15.69%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 8 people, 15.69%
Primary Myelofibrosis (primary disorder of the bone marrow): 5 people, 9.80%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 5 people, 9.80%
Pain: 4 people, 7.84%
High Blood Pressure: 4 people, 7.84%
Depression: 4 people, 7.84%
Breast Cancer Female: 4 people, 7.84%
Type 2 Diabetes: 3 people, 5.88%
Stress And Anxiety: 3 people, 5.88%

* Approximation only. Some reports may have incomplete information.

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