Efudex and Protonix drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Efudex (fluorouracil) and Protonix (pantoprazole sodium). Common drug interactions include fatigue among females and cardiac failure congestive among males.

The phase IV clinical study analyzes what interactions people have when they take Efudex and Protonix. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Efudex?

Efudex has active ingredients of fluorouracil. It is often used in actinic keratosis. eHealthMe is studying from 1,391 Efudex users. Check the latest studies of Efudex.

What is Protonix?

Protonix has active ingredients of pantoprazole sodium. It is often used in gastroesophageal reflux disease. eHealthMe is studying from 132,658 Protonix users. Check the latest studies of Protonix.

On Jul, 12, 2026

24 people who take Efudex and Protonix together, and have interactions are studied.

What are the common drug interactions of Efudex and Protonix, by gender? *:

female:

Fatigue (feeling of tiredness)
Headache (pain in head)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Nausea (feeling of having an urge to vomit)
Neck pain
Osteonecrosis of jaw (death of bone of jaw)
Pulmonary embolism (blockage of the main artery of the lung)
Spinal osteoarthritis (joint cartilage loss in spine)
Abdominal discomfort
Abdominal distension

male:

Cardiac failure congestive
Cellulitis (infection under the skin)
Gait disturbance
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pleural effusion (water on the lungs)
Abdominal distension
Abdominal tenderness
Anxiety disorder
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Aortic valve incompetence

What are the common drug interactions of Efudex and Protonix, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Emotional distress
Pain
Abdominal pain
Anxiety
Arrhythmia (irregular heartbeat)
Aspartate aminotransferase increased
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Blood alkaline phosphatase increased
Blood bilirubin increased

50-59:

Alopecia (absence of hair from areas of the body)
Colon cancer
Gastric cancer (stomach cancer)
Hair colour changes
Hair disorder
Psychological trauma

60+:

Cardiac failure congestive
Cellulitis (infection under the skin)
Cholecystitis chronic (long lasting infection of gallbladder)
Gait disturbance
Haemorrhagic anaemia (anaemia due to excessive bleeding)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Peripheral arterial occlusive disease (reproducible ischemic muscle pain)
Pleural effusion (water on the lungs)
Abdominal distension
Abdominal tenderness

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 4 people, 16.67%
High Blood Pressure: 3 people, 12.50%
High Blood Cholesterol: 3 people, 12.50%
Gout (uric acid crystals building up in the body): 3 people, 12.50%
Pain: 2 people, 8.33%
Multiple Myeloma (cancer of the plasma cells): 2 people, 8.33%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 2 people, 8.33%
Cardiac Failure Congestive: 2 people, 8.33%
Breast Cancer Female: 2 people, 8.33%
Arterial Occlusive Disease (slow process through which arteries throughout the body become progressively narrowed and eventually completely blocked): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Efudex and Protonix?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously