Efudex and Zide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Efudex (fluorouracil) and Zide (hydrochlorothiazide). Common drug interactions include basal cell carcinoma among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Efudex and Zide. It is created by eHealthMe based on reports of 35 people who take the same drugs from the FDA, and is updated regularly.

What is Efudex?

Efudex has active ingredients of fluorouracil. It is often used in actinic keratosis. eHealthMe is studying from 1,391 Efudex users. Check the latest studies of Efudex.

What is Zide?

Zide has active ingredients of hydrochlorothiazide. It is often used in high blood pressure. eHealthMe is studying from 183,246 Zide users. Check the latest studies of Zide.

On Jul, 11, 2026

35 people who take Efudex and Zide together, and have interactions are studied.

What are the common drug interactions of Efudex and Zide, by gender? *:

female:

Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Drug effect decreased
Gastroenteritis (inflammation of stomach and intestine)
Hospitalisation
Productive cough
Pruritus (severe itching of the skin)
Angioedema (rapid swelling of the dermis)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Burning sensation
Chest discomfort

male:

Death
Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Apnoea (suspension of external breathing)
Arthralgia (joint pain)
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)
Atrial tachycardia (rhythm disturbance that arises in the atria)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)

What are the common drug interactions of Efudex and Zide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Chest discomfort
Pruritus (severe itching of the skin)
Vomiting

40-49:

Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Burning sensation
Drug effect decreased
Hypotension (abnormally low blood pressure)
Influenza like illness
Neoplasm (tumour)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Rash
Rash pruritic (redness with itching)

50-59:

Anxiety
Emotional distress
Hepatic enzyme increased
Alopecia (absence of hair from areas of the body)
Hair colour changes
Hair disorder
Depression
Alopecia areata (patchy baldness that typically begins with rapid hair loss)
Diarrhoea
Gastroenteritis (inflammation of stomach and intestine)

60+:

Basal cell carcinoma (a skin cancer, it rarely metastasizes or kills)
Death
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Apnoea (suspension of external breathing)
Arthralgia (joint pain)
Asthenia (weakness)
Atelectasis (partial or complete collapse of the lung)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Atrial flutter (an abnormal heart rhythm that occurs in the atria of the heart)

What are the existing conditions these people have? *

Breast Cancer Female: 9 people, 25.71%
Multiple Myeloma (cancer of the plasma cells): 3 people, 8.57%
Skin Cancer: 2 people, 5.71%
Hypokalemia (low potassium): 2 people, 5.71%
Burkitt Lymphoma (cancer of the lymphatic system): 2 people, 5.71%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 2 people, 5.71%
Constipation: 2 people, 5.71%
Depression: 2 people, 5.71%
Headache (pain in head): 2 people, 5.71%
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 2 people, 5.71%

* Approximation only. Some reports may have incomplete information.

Do you take Efudex and Zide?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously