Elavil and Alphagan drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Elavil (amitriptyline hydrochloride) and Alphagan (brimonidine tartrate). Common drug interactions include acute myocardial infarction among females and asthenia among males.

The phase IV clinical study analyzes what interactions people have when they take Elavil and Alphagan. It is created by eHealthMe based on reports of 19 people who take the same drugs from the FDA, and is updated regularly.

What is Elavil?

Elavil has active ingredients of amitriptyline hydrochloride. It is often used in depression. eHealthMe is studying from 20,724 Elavil users. Check the latest studies of Elavil.

What is Alphagan?

Alphagan has active ingredients of brimonidine tartrate. It is often used in glaucoma. eHealthMe is studying from 9,981 Alphagan users. Check the latest studies of Alphagan.

On Jul, 06, 2026

19 people who take Elavil and Alphagan together, and have interactions are studied.

What are the common drug interactions of Elavil and Alphagan, by gender? *:

female:

Acute myocardial infarction (acute heart attack)
Anaemia (lack of blood)
Anxiety
Aortic valve disease
Autoimmune hepatitis
Blood thyroid stimulating hormone decreased
Blood thyroid stimulating hormone increased
Cardiac disorder
Cataract (clouding of the lens inside the eye)
Cellulitis (infection under the skin)

male:

Asthenia (weakness)
Asthma
Cardiomegaly (increased size of heart than normal)
Cataract (clouding of the lens inside the eye)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Chest pain
Confusional state
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Decreased appetite
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)

What are the common drug interactions of Elavil and Alphagan, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Fatigue (feeling of tiredness)
Flushing (the warm, red condition of human skin)

40-49:

n/a

50-59:

Eye inflammation
Cellulitis (infection under the skin)

60+:

Anaemia (lack of blood)
Asthenia (weakness)
Abdominal pain upper
Arteriosclerosis (thickening and hardening of arteries)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Bundle branch block right (absence of transmission of electric impulses from the atrioventricular (av) bundle of his to the right ventricle)
Cardiac murmur (an heart sound in valve abnormality)
Cardiomegaly (increased size of heart than normal)
Cataract (clouding of the lens inside the eye)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 15.79%
High Blood Pressure: 3 people, 15.79%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 10.53%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 10.53%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 10.53%
Osteoporosis (bones weak and more likely to break): 2 people, 10.53%
Sleep Disorder: 2 people, 10.53%
Cardiac Disorder: 1 person, 5.26%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 5.26%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

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