Elavil and Diamox drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Elavil (amitriptyline hydrochloride) and Diamox (acetazolamide). Common drug interactions include pulmonary embolism among females and anhedonia among males.

The phase IV clinical study analyzes what interactions people have when they take Elavil and Diamox. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Elavil?

Elavil has active ingredients of amitriptyline hydrochloride. It is often used in depression. eHealthMe is studying from 20,724 Elavil users. Check the latest studies of Elavil.

What is Diamox?

Diamox has active ingredients of acetazolamide. It is often used in pseudotumor cerebri. eHealthMe is studying from 4,711 Diamox users. Check the latest studies of Diamox.

On Jul, 17, 2026

24 people who take Elavil and Diamox together, and have interactions are studied.

What are the common drug interactions of Elavil and Diamox, by gender? *:

female:

Pulmonary embolism (blockage of the main artery of the lung)
Renal failure acute (rapid kidney dysfunction)
Renal failure chronic (long lasting kidney dysfunction)
Retinopathy (acute damage to the retina of the eye)
Tibia fracture (fracture of lower leg bone)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Vena cava thrombosis (clotting of the blood in large vein carrying deoxygenated blood into the heart)
Abdominal compartment syndrome (increased pressure in abdomen)
Adrenal insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids)
Ascites (accumulation of fluid in the abdominal cavity)

male:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Bone pain
Breakthrough pain
Cholecystitis infective (infection of gallbladder capable to infect other organs)
Chronic kidney disease
Decreased appetite
Excessive granulation tissue (excessive collagen-rich tissue which forms at the site of an injury)
General physical health deterioration (weak health status)
Gingival disorder (gum disease)

What are the common drug interactions of Elavil and Diamox, by age (0-1 to 60+)? *:

0-1:

Abdominal compartment syndrome (increased pressure in abdomen)
Ascites (accumulation of fluid in the abdominal cavity)
Blood lactic acid increased
Cholecystitis (infection of gallbladder)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Coagulopathy (blood's ability to clot is impaired)
Duodenal perforation (complication of duodenal ulcer)
Enterococcal infection
Fluid retention (an abnormal accumulation of fluid in the blood)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

2-9:

n/a

10-19:

Anxiety
Emotional distress
General physical health deterioration (weak health status)
Injury
Jugular vein thrombosis (clot in jugular vein)
Pain
Pulmonary embolism (blockage of the main artery of the lung)
Vena cava thrombosis (clotting of the blood in large vein carrying deoxygenated blood into the heart)
Bile duct stone
Cholecystitis chronic (long lasting infection of gallbladder)

20-29:

n/a

30-39:

Hyperhidrosis (abnormally increased sweating)
Injection site pain
Intracranial pressure increased (high pressure inside the skull and thus in the brain tissue and cerebrospinal fluid)
Loss of employment
Lower respiratory tract infection
Malaise (a feeling of general discomfort or uneasiness)
Mitral valve incompetence (inefficient heart valve)
Muscle spasms (muscle contraction)
Muscle tightness
Muscular weakness (muscle weakness)

40-49:

Chronic kidney disease
Death
Contusion (a type of hematoma of tissue in which capillaries)
Dysphagia (a condition in which swallowing is difficult or painful)
Fatigue (feeling of tiredness)
Fungal infection

50-59:

Cardiac failure congestive
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Macular oedema (fluid and protein deposits collect on or under the macula of the eye (a yellow central area of the retina) and causes it to thicken)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Renal failure acute (rapid kidney dysfunction)
Renal failure chronic (long lasting kidney dysfunction)
Retinopathy (acute damage to the retina of the eye)
Tibia fracture (fracture of lower leg bone)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Chronic kidney disease

60+:

Pneumonia
Abdominal distension
Breakthrough pain
Cholecystitis infective (infection of gallbladder capable to infect other organs)
Decreased appetite
Dizziness
Dyspnoea (difficult or laboured respiration)
Excessive granulation tissue (excessive collagen-rich tissue which forms at the site of an injury)
General physical health deterioration (weak health status)
Gingival disorder (gum disease)

What are the existing conditions these people have? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 3 people, 12.50%
Prostate Cancer: 3 people, 12.50%
Oedema (fluid collection in tissue): 3 people, 12.50%
Malaria (a parasitic disease due to mosquito bite): 3 people, 12.50%
Infection: 3 people, 12.50%
High Blood Pressure: 3 people, 12.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 12.50%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 2 people, 8.33%
Headache (pain in head): 2 people, 8.33%
Ankylosing Spondylitis (type of arthritis affecting the spine): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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