Elavil and Prinzide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Elavil (amitriptyline hydrochloride) and Prinzide (hydrochlorothiazide; lisinopril). Common drug interactions include suicidal ideation among females and hypoacusis among males.

The phase IV clinical study analyzes what interactions people have when they take Elavil and Prinzide. It is created by eHealthMe based on reports of 22 people who take the same drugs from the FDA, and is updated regularly.

What is Elavil?

Elavil has active ingredients of amitriptyline hydrochloride. It is often used in depression. eHealthMe is studying from 20,724 Elavil users. Check the latest studies of Elavil.

What is Prinzide?

Prinzide has active ingredients of hydrochlorothiazide; lisinopril. It is often used in high blood pressure. eHealthMe is studying from 2,218 Prinzide users. Check the latest studies of Prinzide.

On Aug, 12, 2026

22 people who take Elavil and Prinzide together, and have interactions are studied.

What are the common drug interactions of Elavil and Prinzide, by gender? *:

female:

Suicidal ideation
Visual impairment
Anaemia of chronic disease
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Blood creatine phosphokinase increased
Blood pressure decreased
Cardiac failure congestive
Coagulopathy (blood's ability to clot is impaired)
Collapse of lung (functional breakdown of lung)
Coma (state of unconsciousness lasting more than six hours)

male:

Hypoacusis (loss of hearing)
Intervertebral disc protrusion (spinal disc protrusion)
Panic reaction
Spinal osteoarthritis (joint cartilage loss in spine)
Actinic elastosis (disorder in which the skin appears yellow and thickened as a result of sun damage)
Actinic keratosis (skin disease due to sun exposure)
Adjustment disorder with mixed anxiety and depressed mood
Anaemia (lack of blood)
Androgen deficiency
Anxiety disorder

What are the common drug interactions of Elavil and Prinzide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Suicide attempt
Depressed level of consciousness
Pulmonary embolism (blockage of the main artery of the lung)
Respiratory arrest (cessation of normal respiration due to failure of the lungs to function effectively)
Suicidal ideation
Back pain
Chest pain
Coma (state of unconsciousness lasting more than six hours)

60+:

Hypoacusis (loss of hearing)
Anxiety
Myalgia (muscle pain)
Neuropathy (damage to nerves)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteoporosis (bones weak and more likely to break)
Panic reaction
Pneumonia
Pneumothorax (the presence of air or gas in the cavity between the lungs and the chest wall, causing collapse of the lung)
Spinal osteoarthritis (joint cartilage loss in spine)

What are the existing conditions these people have? *

Pain: 6 people, 27.27%
Quit Smoking: 3 people, 13.64%
High Blood Cholesterol: 3 people, 13.64%
Stress And Anxiety: 2 people, 9.09%
Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously): 2 people, 9.09%
Neuropathy Peripheral (surface nerve damage): 2 people, 9.09%
Gastric Disorder (disease of stomach): 2 people, 9.09%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 2 people, 9.09%
Blood Pressure Abnormal: 2 people, 9.09%
Blood Disorder: 2 people, 9.09%

* Approximation only. Some reports may have incomplete information.

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