Elavil and Rocaltrol drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Elavil (amitriptyline hydrochloride) and Rocaltrol (calcitriol). Common drug interactions include somnolence among females and colon cancer metastatic among males.
The phase IV clinical study analyzes what interactions people have when they take Elavil and Rocaltrol. It is created by eHealthMe based on reports of 41 people who take the same drugs from the FDA, and is updated regularly.
What is Elavil?
Elavil has active ingredients of amitriptyline hydrochloride. It is often used in depression. eHealthMe is studying from 20,724 Elavil users. Check the latest studies of Elavil.
What is Rocaltrol?
Rocaltrol has active ingredients of calcitriol. It is often used in hypoparathyroidism. eHealthMe is studying from 7,562 Rocaltrol users. Check the latest studies of Rocaltrol.
41 people who take Elavil and Rocaltrol together, and have interactions are studied.

What are the common drug interactions of Elavil and Rocaltrol, by gender? *:
female:
- Somnolence (a state of near-sleep, a strong desire for sleep)
- Wound
- Abasia (inability to walk)
- Abdominal hernia
- Abdominal pain upper
- Blood potassium decreased
- Cardiac arrest
- Cardiomyopathy (weakening of the heart muscle)
- Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
- Chest pain
male:
- Colon cancer metastatic (cancer of colon spreads to other part of body)
- Chronic kidney disease
- Activities of daily living impaired
- Anaemia (lack of blood)
- Anxiety
- Arteriosclerosis coronary artery (thickening and hardening of arteries- coronary artery)
- Ascites (accumulation of fluid in the abdominal cavity)
- Asthenia (weakness)
- Azotaemia (excess of urea or other nitrogenous compounds in the blood)
- Balance disorder
What are the common drug interactions of Elavil and Rocaltrol, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
- Abasia (inability to walk)
- Asthenia (weakness)
- Dysarthria (speech disorder)
- Abdominal pain upper
- Anorexia (eating disorder characterized by immoderate food restriction and irrational fear of gaining weight)
30-39:
- Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
- Somnolence (a state of near-sleep, a strong desire for sleep)
- Abdominal pain
- Nausea (feeling of having an urge to vomit)
- Septic shock (shock due to blood infection)
- Vomiting
- Abdominal pain upper
- Cardiac failure acute
- Cerebral infarction (less blood supply to brain resulting tissue damage)
- Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
40-49:
- Blood calcium decreased
- Chest pain
- Hypercalcaemia (elevated calcium (ca+) level in the blood)
50-59:
- Blood creatinine increased
- Chronic kidney disease
- Renal failure (kidney dysfunction)
- Abdominal hernia
- Chills (felling of cold)
- Dehydration (dryness resulting from the removal of water)
- Dysuria (painful or difficult urination)
- Fluid retention (an abnormal accumulation of fluid in the blood)
- Kidney transplant rejection
- Mobility decreased (ability to move is reduced)
60+:
- Chronic kidney disease
- Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
- Hospitalisation
- Malaise (a feeling of general discomfort or uneasiness)
- Pneumonia
- Sepsis (a severe blood infection that can lead to organ failure and death)
- Therapeutic response unexpected
- Vein disorder
- Vomiting
- Anaemia (lack of blood)
What are the existing conditions these people have? *
- Pain: 14 people, 34.15%
- Stress And Anxiety: 11 people, 26.83%
- Neuralgia (pain in one or more nerves): 10 people, 24.39%
- Nausea (feeling of having an urge to vomit): 9 people, 21.95%
- Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 19.51%
- Fluid Retention (an abnormal accumulation of fluid in the blood): 6 people, 14.63%
- Urinary Tract Infection: 5 people, 12.20%
- Constipation: 5 people, 12.20%
- Diarrhea: 5 people, 12.20%
- High Blood Pressure: 5 people, 12.20%
* Approximation only. Some reports may have incomplete information.
Do you take Elavil and Rocaltrol?
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Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Elavil and Rocaltrol:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Elavil:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Rocaltrol:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Elavil and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Rocaltrol and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zRelated publications that referenced our studies
- Li W, Lamichhane J, "From Heartbreak to Left Bundle Branch Block: A Case of Amitriptyline Overdose", American Journal of Therapeutics, 2017 Sep .
- Li W, Lamichhane J, "From Heartbreak to Left Bundle Branch Block: A Case of Amitriptyline Overdose", American Journal of Therapeutics, 2017 Sep .
How the study uses the data?
The study uses data from the FDA. It is based on amitriptyline hydrochloride and calcitriol (the active ingredients of Elavil and Rocaltrol, respectively), and Elavil and Rocaltrol (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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