Eliquis and Benlysta drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Eliquis (apixaban) and Benlysta (belimumab). Common drug interactions include osteonecrosis among females and gallbladder operation among males.

The phase IV clinical study analyzes what interactions people have when they take Eliquis and Benlysta. It is created by eHealthMe based on reports of 78 people who take the same drugs from the FDA, and is updated regularly.

What is Eliquis?

Eliquis has active ingredients of apixaban. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 191,859 Eliquis users. Check the latest studies of Eliquis.

What is Benlysta?

Benlysta has active ingredients of belimumab. It is often used in systemic lupus erythematosus. eHealthMe is studying from 23,528 Benlysta users. Check the latest studies of Benlysta.

On Jul, 06, 2026

78 people who take Eliquis and Benlysta together, and have interactions are studied.

What are the common drug interactions of Eliquis and Benlysta, by gender? *:

female:

Osteonecrosis (death of bone)
Fall
Gastritis haemorrhagic (inflammation of stomach with bleeding)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)
Leukopenia (less number of white blood cells in blood)
Lymphopenia (an abnormally low level of lymphocytes in the blood)
Pancreatitis acute (sudden inflammation of pancreas)
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)

male:

Gallbladder operation

What are the common drug interactions of Eliquis and Benlysta, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Dyspnoea (difficult or laboured respiration)
Physical assault

30-39:

Cardiac failure
Pulmonary thrombosis (scarring in the lungs)
Osteonecrosis (death of bone)
Pain
Cardiac failure congestive
Hip arthroplasty
Lymphadenopathy (disease or enlargement of lymph nodes)
Influenza
Drug ineffective

40-49:

Sinusitis (inflammation of sinus)
Poor venous access
Dehydration (dryness resulting from the removal of water)
Malaise (a feeling of general discomfort or uneasiness)
Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves)
Oxygen consumption increased
Pain
Respiratory syncytial virus infection (viral disease of respiratory system)
Upper respiratory tract infection

50-59:

Hypertension (high blood pressure)
Urticaria (rash of round, red welts on the skin that itch intensely)
Antiphospholipid syndrome (disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss)
Anxiety disorder
Colitis ulcerative (inflammation of colon with ulcer)
Complex regional pain syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet))
Coombs positive haemolytic anaemia
Depression
Drug hypersensitivity
Erysipelas (bacterial skin infection)

60+:

Antiphospholipid syndrome (disorder that manifests clinically as recurrent venous or arterial thrombosis and/or fetal loss)
Anxiety disorder
Erysipelas (bacterial skin infection)
Fall
Feeling drunk
Gastritis haemorrhagic (inflammation of stomach with bleeding)
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypertension (high blood pressure)
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development)

What are the existing conditions these people have? *

White Blood Cell Count Decreased: 27 people, 34.62%
Pain: 17 people, 21.79%
Lymphopenia (an abnormally low level of lymphocytes in the blood): 17 people, 21.79%
Immunodeficiency Common Variable: 6 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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