Eliquis and Efudex drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Eliquis (apixaban) and Efudex (fluorouracil). Common drug interactions include nausea among females and pneumonia among males.

The phase IV clinical study analyzes what interactions people have when they take Eliquis and Efudex. It is created by eHealthMe based on reports of 43 people who take the same drugs from the FDA, and is updated regularly.

What is Eliquis?

Eliquis has active ingredients of apixaban. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 191,861 Eliquis users. Check the latest studies of Eliquis.

What is Efudex?

Efudex has active ingredients of fluorouracil. It is often used in actinic keratosis. eHealthMe is studying from 1,391 Efudex users. Check the latest studies of Efudex.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

43 people who take Eliquis and Efudex together, and have interactions are studied.

What are the common drug interactions of Eliquis and Efudex, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Neoplasm (tumour)
Postoperative wound infection
Seborrhoeic keratosis (noncancerous (benign) skin growths that some people develop as they age. they often appear on the back or chest)
Skin wound
Squamous cell carcinoma of skin (a cancer of a kind of epithelial cell, the squamous cell. these cells are the main part of the epidermis of the skin)
Peripheral swelling
Adverse event
Incision site haemorrhage (bleeding from incision site)
Bacteraemia (presence of bacteria in the blood)

male:

Pneumonia
Road traffic accident
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypokalaemia (low potassium)
Pleural effusion (water on the lungs)
Sepsis (a severe blood infection that can lead to organ failure and death)
Thrombocytopenia (decrease of platelets in blood)
Transaminases increased
Asthenia (weakness)
Blood pressure increased

What are the common drug interactions of Eliquis and Efudex, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Anxiety
Chronic kidney disease
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Oedema peripheral (superficial swelling)
Renal failure (kidney dysfunction)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)

60+:

Pneumonia
Road traffic accident
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypokalaemia (low potassium)
Pleural effusion (water on the lungs)
Sepsis (a severe blood infection that can lead to organ failure and death)
Thrombocytopenia (decrease of platelets in blood)
Transaminases increased
Asthenia (weakness)
Blood pressure increased

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 12 people, 27.91%
Nausea (feeling of having an urge to vomit): 11 people, 25.58%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 6 people, 13.95%
Diarrhea: 4 people, 9.30%
Sleep Disorder: 4 people, 9.30%
Blood Pressure Abnormal: 4 people, 9.30%
Prostate Cancer: 3 people, 6.98%
Short-Bowel Syndrome (a condition in which the body cannot absorb enough fluids and nutrients because part of the small intestine is missing): 3 people, 6.98%
Mineral Deficiency (lack of mineral): 3 people, 6.98%
Skin Cancer: 3 people, 6.98%

* Approximation only. Some reports may have incomplete information.

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