Eliquis and Fetzima drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Eliquis (apixaban) and Fetzima (levomilnacipran hydrochloride). Common drug interactions include flatulence among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Eliquis and Fetzima. It is created by eHealthMe based on reports of 23 people who take the same drugs from the FDA, and is updated regularly.

What is Eliquis?

Eliquis has active ingredients of apixaban. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 191,859 Eliquis users. Check the latest studies of Eliquis.

What is Fetzima?

Fetzima has active ingredients of levomilnacipran hydrochloride. It is often used in depression. eHealthMe is studying from 2,077 Fetzima users. Check the latest studies of Fetzima.

On Jul, 07, 2026

23 people who take Eliquis and Fetzima together, and have interactions are studied.

What are the common drug interactions of Eliquis and Fetzima, by gender? *:

female:

Flatulence (flatus expelled through the anus)
Fungal infection
Heart rate increased
Hyperhidrosis (abnormally increased sweating)
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)
Nausea (feeling of having an urge to vomit)
Pain
Vomiting
Adverse event
Anaemia (lack of blood)

male:

Death
Psoriasis (immune-mediated disease that affects the skin)
Blood pressure decreased
Diarrhoea
Lacrimation increased
Post-traumatic stress disorder
Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve)
Shoulder operation
Skin irritation

What are the common drug interactions of Eliquis and Fetzima, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Cystitis (inflammation of the wall of the bladder)
Device dislocation
Dyspareunia (painful sexual intercourse)
Menstruation delayed (late menstruation cycle)
Urinary tract infection

30-39:

n/a

40-49:

Blood cholesterol increased
Joint stiffness
Muscular weakness (muscle weakness)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Swelling face
Weight increased

50-59:

Abdominal pain
Amylase decreased
Diarrhoea
Gallbladder disorder
Malaise (a feeling of general discomfort or uneasiness)
Nausea (feeling of having an urge to vomit)
Weight decreased

60+:

Blood pressure increased
Death
Diarrhoea
Urinary tract infection
Flatulence (flatus expelled through the anus)
Fungal infection
Heart rate increased
Hyperhidrosis (abnormally increased sweating)
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection)
Pain

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 17.39%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 4 people, 17.39%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 3 people, 13.04%
Multiple Myeloma (cancer of the plasma cells): 3 people, 13.04%
Migraine (headache): 3 people, 13.04%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 13.04%
Stress And Anxiety: 2 people, 8.70%
Sleep Disorder: 2 people, 8.70%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 8.70%
Pain: 2 people, 8.70%

* Approximation only. Some reports may have incomplete information.

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