Eliquis and Synjardy drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Eliquis (apixaban) and Synjardy (empagliflozin; metformin hydrochloride). Common drug interactions include headache among females and arthralgia among males.

The phase IV clinical study analyzes what interactions people have when they take Eliquis and Synjardy. It is created by eHealthMe based on reports of 64 people who take the same drugs from the FDA, and is updated regularly.

What is Eliquis?

Eliquis has active ingredients of apixaban. It is often used in atrial fibrillation/flutter. eHealthMe is studying from 191,861 Eliquis users. Check the latest studies of Eliquis.

What is Synjardy?

Synjardy has active ingredients of empagliflozin; metformin hydrochloride. eHealthMe is studying from 2,928 Synjardy users. Check the latest studies of Synjardy.

On Aug, 12, 2026

64 people who take Eliquis and Synjardy together, and have interactions are studied.

What are the common drug interactions of Eliquis and Synjardy, by gender? *:

female:

Headache (pain in head)
Initial insomnia (feeling of inadequate or poor-quality sleep)
Insomnia (sleeplessness)
Kidney infection
Loss of consciousness
Malaise (a feeling of general discomfort or uneasiness)
Mastoiditis (infection of mastoid bone)
Muscle spasms (muscle contraction)
Neuropathy peripheral (surface nerve damage)
Oropharyngeal discomfort (pain or irritation of oropharynx)

male:

Arthralgia (joint pain)
Pain in extremity
Blood pressure increased
Dizziness
Hypotension (abnormally low blood pressure)
Loss of consciousness
Lyme disease (a bacterial infection that is spread to humans by infected ticks)
Myopathy (a muscular disease in which the muscle fibres do not function)
Myositis (inflammation of the muscles)
Psoriasis (immune-mediated disease that affects the skin)

What are the common drug interactions of Eliquis and Synjardy, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Arthralgia (joint pain)
Pain in extremity
Gait disturbance
Joint range of motion decreased (disease of joint movement)
Ligament sprain (ligament stretched)
Blood glucose increased
Device failure

50-59:

Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Cushing's syndrome (obesity, a rounded face, increased fat)
Exostosis (formation of new bone on the surface of a bone)
Nasopharyngitis (inflammation of the nasopharynx)
Platelet count decreased
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Hyperglycaemia (high blood sugar)
Hypotension (abnormally low blood pressure)
Impaired healing
Mastication disorder (disease of chewing food)

60+:

Fatigue (feeling of tiredness)
Blood pressure increased
Glycosylated haemoglobin increased
Lactic acidosis (low ph in body tissues)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Alopecia (absence of hair from areas of the body)
Glossitis (infection of tongue with soreness)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Rash

What are the existing conditions these people have? *

Type 2 Diabetes: 11 people, 17.19%
Multiple Myeloma (cancer of the plasma cells): 9 people, 14.06%
High Blood Pressure: 8 people, 12.50%
Diabetes: 6 people, 9.38%
Renal Cell Carcinoma (a kidney cancer): 5 people, 7.81%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 6.25%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 6.25%

* Approximation only. Some reports may have incomplete information.

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