Elspar and Hydrocortisone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Elspar (asparaginase) and Hydrocortisone (hydrocortisone). Common drug interactions include mucosal inflammation among females and sepsis among males.

The phase IV clinical study analyzes what interactions people have when they take Elspar and Hydrocortisone. It is created by eHealthMe based on reports of 74 people who take the same drugs from the FDA, and is updated regularly.

What is Elspar?

Elspar has active ingredients of asparaginase. eHealthMe is studying from 2,057 Elspar users. Check the latest studies of Elspar.

What is Hydrocortisone?

Hydrocortisone has active ingredients of hydrocortisone. It is often used in addison's disease. eHealthMe is studying from 40,425 Hydrocortisone users. Check the latest studies of Hydrocortisone.

On Jul, 19, 2026

74 people who take Elspar and Hydrocortisone together, and have interactions are studied.

Elspar and Hydrocortisone drug interactions.

What are the common drug interactions of Elspar and Hydrocortisone, by gender? *:

female:

Mucosal inflammation (infection of mucous membrane)
Vomiting
Neutropenia (an abnormally low number of neutrophils)
Pyrexia (fever)
Thrombocytopenia (decrease of platelets in blood)
White blood cell count decreased
Enterocolitis (inflammation of the digestive tract, involving enteritis of the small intestine and colitis of the colon)
Hypoaesthesia (reduced sense of touch or sensation)
Hypokalaemia (low potassium)
Nausea (feeling of having an urge to vomit)

male:

Sepsis (a severe blood infection that can lead to organ failure and death)
Neuropathy peripheral (surface nerve damage)
Pneumonia
Status epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure)
Superior sagittal sinus thrombosis (blood clot in the dural venous sinuses, which drain blood from the brain)
Abnormal behaviour
Antithrombin iii decreased
Areflexia (absence of a reflex)
Blood fibrinogen decreased
Blood osmolarity increased

What are the common drug interactions of Elspar and Hydrocortisone, by age (0-1 to 60+)? *:

0-1:

Diarrhoea
Neutropenia (an abnormally low number of neutrophils)
Pyrexia (fever)
Vomiting
Abdominal distension
Bone marrow depression (decreased ability or inability of the bone marrow to produce blood cells)
Bowel sounds
Bradycardia (abnormally slow heart action)
Bronchopulmonary aspergillosis (lung disorder caused by aspergillus fungi)
Cardio-respiratory arrest (sudden dysfunction of heart and lungs)

2-9:

Chest pressure sensation (feeling of pressure on chest)
Colitis (inflammation of colon)
Cough
Csf culture positive
Depressed level of consciousness
Difficulty in walking
Diplegia (paralysis of corresponding parts on both sides of the body)
Drug hypersensitivity
Enterocolitis infectious
Excessive eye blinking (excessive blinking is dry eyes)

10-19:

Hypoaesthesia (reduced sense of touch or sensation)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Blood pressure increased
Coagulopathy (blood's ability to clot is impaired)
Heart rate increased
Hypertension (high blood pressure)
Lethargy (tiredness)
Neuropathy peripheral (surface nerve damage)
Pulmonary haemorrhage (acute bleeding from the lung)
Respiratory disorder (respiratory disease)

20-29:

Neutrophil count decreased (less than normal number of neutrophil a type of blood cell)
White blood cell count decreased
Enterocolitis infectious
Fluid retention (an abnormal accumulation of fluid in the blood)
Headache (pain in head)
Hypertension (high blood pressure)
Blood alkaline phosphatase increased
Blood bilirubin increased
Cholecystitis (infection of gallbladder)
Gamma-glutamyltransferase increased

30-39:

Csf immunoglobulin increased
Csf protein increased
Febrile neutropenia (fever with reduced white blood cells)
Pneumonia bacterial (pneumonia associated with bacterial infection)
Radiculopathy (a set of conditions in which one or more nerves is affected and does not work properly)
Respiratory tract infection
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary incontinence (inability to control the flow of urine and involuntary urination)
Urinary retention (the inability to completely or partially empty the bladder)
Urinary tract infection

40-49:

Pneumonia
Denervation atrophy (interruption of the nerve connection to an organ waste away)
Hepatic failure (liver failure)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Lividity (a tissue condition of being red or blue because of venous congestion, as in a contusion)
Lumbar radiculopathy (radicular pain in the low back and legs)
Multi-organ failure (multisystem organ failure)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Rash erythematous (redness of the skin)
Renal failure (kidney dysfunction)

50-59:

n/a

60+:

Abdominal pain
Ammonia increased
Meningitis (inflammation of the protective membranes covering the brain and spinal cord, known collectively as the meninges)
Pancreatitis (inflammation of pancreas)
Sepsis (a severe blood infection that can lead to organ failure and death)
Bacterial infection
Cardiovascular disorder (heart diseases)
Cellulitis (infection under the skin)
Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall)
Gastrointestinal obstruction

What are the existing conditions these people have? *

Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 20 people, 27.03%

* Approximation only. Some reports may have incomplete information.

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