Emend and Doxycycline hyclate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Emend (aprepitant) and Doxycycline hyclate (doxycycline hyclate). Common drug interactions include blister among females and cytokine release syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Emend and Doxycycline hyclate. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Emend?

Emend has active ingredients of aprepitant. It is often used in nausea. eHealthMe is studying from 13,741 Emend users. Check the latest studies of Emend.

What is Doxycycline hyclate?

Doxycycline hyclate has active ingredients of doxycycline hyclate. It is often used in acne. eHealthMe is studying from 17,880 Doxycycline hyclate users. Check the latest studies of Doxycycline hyclate.

On Sep, 24, 2025

56 people who take Emend and Doxycycline hyclate together, and have interactions are studied.

Emend and Doxycycline hyclate drug interactions.

What are the common drug interactions of Emend and Doxycycline Hyclate, by gender? *:

female:

Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Hand deformity
Hepatic enzyme increased
Joint swelling
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Fatigue (feeling of tiredness)
Glossodynia (a burning or painful sensation in the tongue)
Helicobacter infection (helicobacter pylori (h. pylori) infects stomach)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pericarditis (inflammation of the pericardium)

male:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Mucosal inflammation (infection of mucous membrane)
Neutropenia (an abnormally low number of neutrophils)
Prostate cancer
Pyrexia (fever)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Corneal abrasion (loss of the surface of cornea)

What are the common drug interactions of Emend and Doxycycline Hyclate, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Alopecia (absence of hair from areas of the body)
Grip strength decreased
Ill-defined disorder
Anti-cyclic citrullinated peptide antibody positive
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Hand deformity
Hepatic enzyme increased
Joint swelling
Rheumatoid arthritis (a chronic progressive disease causing inflammation in the joints)
Fatigue (feeling of tiredness)

50-59:

Lipase increased
Pancreatitis acute (sudden inflammation of pancreas)

60+:

Cytokine release syndrome (immediate complication occurring with the use of anti-t cell antibody infusions)
Mucosal inflammation (infection of mucous membrane)
Neutropenia (an abnormally low number of neutrophils)
Prostate cancer
Pyrexia (fever)
Rash maculo-papular (red area on the skin that is covered with small confluent bumps)
Corneal abrasion (loss of the surface of cornea)

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 50 people, 89.29%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 50 people, 89.29%
Psoriasis (immune-mediated disease that affects the skin): 33 people, 58.93%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 29 people, 51.79%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 24 people, 42.86%
Inflammation: 21 people, 37.50%
Synovitis (inflammation of the synovial membrane): 20 people, 35.71%
Pemphigus (any of several acute or chronic skin diseases characterized by groups of itching blisters): 19 people, 33.93%
Pain: 19 people, 33.93%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 19 people, 33.93%

* Approximation only. Some reports may have incomplete information.

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