Emend and Loratadine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Emend (aprepitant) and Loratadine (loratadine). Common drug interactions include hyperventilation among females and dehydration among males.

The phase IV clinical study analyzes what interactions people have when they take Emend and Loratadine. It is created by eHealthMe based on reports of 57 people who take the same drugs from the FDA, and is updated regularly.

What is Emend?

Emend has active ingredients of aprepitant. It is often used in nausea. eHealthMe is studying from 13,741 Emend users. Check the latest studies of Emend.

What is Loratadine?

Loratadine has active ingredients of loratadine. It is often used in allergies. eHealthMe is studying from 56,314 Loratadine users. Check the latest studies of Loratadine.

On Jul, 27, 2026

57 people who take Emend and Loratadine together, and have interactions are studied.

What are the common drug interactions of Emend and Loratadine, by gender? *:

female:

Hyperventilation
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Mobility decreased (ability to move is reduced)
Neuropathy peripheral (surface nerve damage)
Neutropenia (an abnormally low number of neutrophils)
Oedema peripheral (superficial swelling)
Oral discomfort (pain or irritation in mouth)
Pain of skin
Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)
Pleural effusion (water on the lungs)

male:

Dehydration (dryness resulting from the removal of water)
Diarrhoea
Renal failure acute (rapid kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Cellulitis (infection under the skin)
Thrombocytopenia (decrease of platelets in blood)
Pain
Interstitial lung disease
Anaemia (lack of blood)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)

What are the common drug interactions of Emend and Loratadine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Arthralgia (joint pain)
Decreased appetite
Dry skin
Erythema (redness of the skin)
Fatigue (feeling of tiredness)
Headache (pain in head)
Hypokalaemia (low potassium)
Oral discomfort (pain or irritation in mouth)
Pain of skin
Paraesthesia oral (sensation of tingling, tickling, prickling, pricking, or burning of a person's oral with no apparent long-term physical effect)

20-29:

n/a

30-39:

Abdominal pain
Disease progression
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Flushing (the warm, red condition of human skin)
Muscle spasms (muscle contraction)
Oedema (fluid collection in tissue)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Vomiting

40-49:

Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hydronephrosis (water inside the kidney)
Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Lymphadenopathy (disease or enlargement of lymph nodes)
Lymphatic obstruction (blockage in lymphatic duct)
Pleural effusion (water on the lungs)
Renal failure acute (rapid kidney dysfunction)

50-59:

Dehydration (dryness resulting from the removal of water)
Diarrhoea
Alopecia (absence of hair from areas of the body)
Anxiety
Emotional distress
Hair colour changes
Hair disorder
Overdose
Pain
Psychological trauma

60+:

Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Sepsis (a severe blood infection that can lead to organ failure and death)
Interstitial lung disease
Cellulitis (infection under the skin)
Colitis (inflammation of colon)
Dehydration (dryness resulting from the removal of water)
Febrile neutropenia (fever with reduced white blood cells)
Pain
Thrombocytopenia (decrease of platelets in blood)

What are the existing conditions these people have? *

Insomnia (sleeplessness): 14 people, 24.56%
Constipation: 11 people, 19.30%
Asthma: 9 people, 15.79%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 15.79%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 8 people, 14.04%
Procedural Pain: 8 people, 14.04%
Depression: 8 people, 14.04%
Diabetes: 8 people, 14.04%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 7 people, 12.28%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 7 people, 12.28%

* Approximation only. Some reports may have incomplete information.

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