Emend and Prezista drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Emend (aprepitant) and Prezista (darunavir ethanolate). Common drug interactions include anuria among females and peripheral motor neuropathy among males.

The phase IV clinical study analyzes what interactions people have when they take Emend and Prezista. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Emend?

Emend has active ingredients of aprepitant. It is often used in nausea. eHealthMe is studying from 13,741 Emend users. Check the latest studies of Emend.

What is Prezista?

Prezista has active ingredients of darunavir ethanolate. It is often used in hiv infection. eHealthMe is studying from 12,363 Prezista users. Check the latest studies of Prezista.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 24, 2026

16 people who take Emend and Prezista together, and have interactions are studied.

What are the common drug interactions of Emend and Prezista, by gender? *:

female:

Anuria (failure of the kidneys to produce urine)
Hepatic enzyme increased
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Abdominal pain upper
General physical health deterioration (weak health status)
Pancytopenia (medical condition in which there is a reduction in the number of red and white blood cells, as well as platelets)
Renal failure acute (rapid kidney dysfunction)
Chest pain
Cough
Dyspnoea (difficult or laboured respiration)

male:

Peripheral motor neuropathy (muscles in the body become progressively weaker over months to years)
Histiocytosis haematophagic
Thrombocytopenia (decrease of platelets in blood)
Hodgkin's disease (cancer originating from white blood cells)
Neuropathy peripheral (surface nerve damage)
Somnolence (a state of near-sleep, a strong desire for sleep)
Abdominal pain
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Intestinal obstruction
Neutropenia (an abnormally low number of neutrophils)

What are the common drug interactions of Emend and Prezista, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Somnolence (a state of near-sleep, a strong desire for sleep)
Neutropenia (an abnormally low number of neutrophils)
Thrombocytopenia (decrease of platelets in blood)

30-39:

Peripheral motor neuropathy (muscles in the body become progressively weaker over months to years)
Histiocytosis haematophagic
Hodgkin's disease (cancer originating from white blood cells)
Neuropathy peripheral (surface nerve damage)
Peripheral sensory neuropathy (damage to one or more of your peripheral nerves)

40-49:

Anuria (failure of the kidneys to produce urine)
Hepatic enzyme increased
Lymphangiosis carcinomatosa (inflammation of the lymph vessels can lead to cancer)
Painful respiration
Renal failure (kidney dysfunction)
Abdominal pain
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Intestinal obstruction
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down)
Abdominal pain upper

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Hiv Test Positive: 7 people, 43.75%
Sarcoma Uterus (type of tumour of uterus cancer): 6 people, 37.50%
Uterine Leiomyosarcoma (uterus cancer of smooth muscle connective tissue): 3 people, 18.75%
Sarcoma (rare cancers that develop in the muscle, bone, nerves, cartilage, tendons, blood vessels and the fatty and fibrous tissues): 2 people, 12.50%
Pain: 2 people, 12.50%
Acquired Immunodeficiency Syndrome (disease of the human immune system caused by the human immunodeficiency virus (hiv)): 2 people, 12.50%
Kaposi's Sarcoma Aids Related (a tumour caused by human herpes virus associated with aids): 1 person, 6.25%
Hodgkin's Lymphoma (cancer originating from white blood cells): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

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