Emend and Samsca drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Emend (aprepitant) and Samsca (tolvaptan). Common drug interactions include blood calcium decreased among females and cardiac failure among males.

The phase IV clinical study analyzes what interactions people have when they take Emend and Samsca. It is created by eHealthMe based on reports of 14 people who take the same drugs from the FDA, and is updated regularly.

What is Emend?

Emend has active ingredients of aprepitant. It is often used in nausea. eHealthMe is studying from 13,741 Emend users. Check the latest studies of Emend.

What is Samsca?

Samsca has active ingredients of tolvaptan. eHealthMe is studying from 8,139 Samsca users. Check the latest studies of Samsca.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

14 people who take Emend and Samsca together, and have interactions are studied.

What are the common drug interactions of Emend and Samsca, by gender? *:

female:

Blood calcium decreased
Blood glucose increased
Blood potassium decreased
Blood uric acid increased
C-reactive protein increased
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cough
Dyspepsia (indigestion)
Dyspnoea (difficult or laboured respiration)
Fall

male:

Cardiac failure
Death

What are the common drug interactions of Emend and Samsca, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Vomiting
Rapid correction of hyponatraemia (rapid correction of abnormally low concentrations of sodium ions in the circulating blood)
Pruritus (severe itching of the skin)
Leukopenia (less number of white blood cells in blood)
Neutropenia (an abnormally low number of neutrophils)
Pneumonia
Hyponatraemia (abnormally low level of sodium in the blood; associated with dehydration)
General physical health deterioration (weak health status)
Thirst
Platelet count decreased

What are the existing conditions these people have? *

Inappropriate Antidiuretic Hormone Secretion: 6 people, 42.86%
Dyspnea (difficult or laboured breathing): 4 people, 28.57%
Hyponatremia (abnormally low level of sodium in the blood; associated with dehydration): 4 people, 28.57%
High Blood Pressure: 3 people, 21.43%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 21.43%
Tumor Pain: 3 people, 21.43%
Constipation: 3 people, 21.43%
Lung Cancer - Small Cell (lung cancer): 3 people, 21.43%
Hypokalemia (low potassium): 2 people, 14.29%
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood): 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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