Emla and Humalog drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Emla (lidocaine; prilocaine) and Humalog (insulin lispro recombinant). Common drug interactions include nausea among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Emla and Humalog. It is created by eHealthMe based on reports of 90 people who take the same drugs from the FDA, and is updated regularly.

What is Emla?

Emla has active ingredients of lidocaine; prilocaine. eHealthMe is studying from 5,276 Emla users. Check the latest studies of Emla.

What is Humalog?

Humalog has active ingredients of insulin lispro recombinant. It is often used in diabetes. eHealthMe is studying from 137,127 Humalog users. Check the latest studies of Humalog.

On Jul, 27, 2026

90 people who take Emla and Humalog together, and have interactions are studied.

What are the common drug interactions of Emla and Humalog, by gender? *:

female:

Nausea (feeling of having an urge to vomit)
Sepsis (a severe blood infection that can lead to organ failure and death)
Dyspnoea (difficult or laboured respiration)
Headache (pain in head)
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking)
Pneumonitis (inflammation of the walls of the alveoli in the lungs)
Urinary retention (the inability to completely or partially empty the bladder)
Actinomycosis (infection that causes sores, or abscesses)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arrhythmia (irregular heartbeat)

male:

Renal failure (kidney dysfunction)
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Hyperparathyroidism secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary)
Impaired work ability
Nephrolithiasis (calculi in the kidneys)
Renal impairment (severely reduced kidney function)
Renal transplant
Tooth loss
Dyspnoea (difficult or laboured respiration)
Nephrogenic anaemia (anaemia due to kidney disease)

What are the common drug interactions of Emla and Humalog, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Infective pulmonary exacerbation of cystic fibrosis (severe infective lung disease with production of abnormally thick mucus)
Abdominal pain
Aspartate aminotransferase increased
Autoimmune thyroiditis (form of thyroiditis associated with an autoimmune disease)
Blood cholesterol increased
Blood triglycerides increased
Coagulopathy (blood's ability to clot is impaired)
Cough
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dehydration (dryness resulting from the removal of water)

20-29:

Drug-induced liver injury (diseases of the liver that are caused by physician-prescribed medications)

30-39:

Abdominal pain upper
Aphasia (damage to the parts of the brain that control language)
Arthralgia (joint pain)
Blood creatinine increased
Blood glucose decreased
Blood urea increased
Chest discomfort
Clumsiness (a lack of coordination or elegance)
Constipation
Dyspareunia (painful sexual intercourse)

40-49:

Renal failure (kidney dysfunction)
Cellulitis (infection under the skin)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Azotaemia (excess of urea or other nitrogenous compounds in the blood)
Decreased activity
Emotional distress
Hyperkalaemia (damage to or disease of the kidney)

50-59:

Bone disorder
Cachexia (loss of weight)
Candidiasis (candidiasis or thrush is a fungal infection)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Congestive cardiomyopathy (weakening of heart muscle)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Cough
Dehydration (dryness resulting from the removal of water)
Delirium (wild excitement)
Dental caries

60+:

Back pain
Pneumonia
Pyrexia (fever)
Anaemia (lack of blood)
Blood creatinine increased
Blood pressure decreased
Chronic kidney disease
Colon cancer
Death
Haemophilus bacteraemia (bacterial infection by haemophilus influenzae)

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 18 people, 20.00%
Pain: 13 people, 14.44%
Depression: 10 people, 11.11%
Nausea And Vomiting: 9 people, 10.00%
Diarrhea: 8 people, 8.89%
Insomnia (sleeplessness): 8 people, 8.89%
High Blood Pressure: 7 people, 7.78%
Indigestion: 6 people, 6.67%
Hypotension (abnormally low blood pressure): 6 people, 6.67%
Haemorrhoids (a swollen vein or group of veins in the region of the anus): 6 people, 6.67%

* Approximation only. Some reports may have incomplete information.

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