Enablex and Fluconazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Enablex (darifenacin hydrobromide) and Fluconazole (fluconazole). Common drug interactions include diarrhoea among females and chronic kidney disease among males.

The phase IV clinical study analyzes what interactions people have when they take Enablex and Fluconazole. It is created by eHealthMe based on reports of 49 people who take the same drugs from the FDA, and is updated regularly.

What is Enablex?

Enablex has active ingredients of darifenacin hydrobromide. It is often used in urge incontinence. eHealthMe is studying from 4,934 Enablex users. Check the latest studies of Enablex.

What is Fluconazole?

Fluconazole has active ingredients of fluconazole. It is often used in vaginal yeast infection. eHealthMe is studying from 70,481 Fluconazole users. Check the latest studies of Fluconazole.

On Jul, 14, 2026

49 people who take Enablex and Fluconazole together, and have interactions are studied.

Enablex and Fluconazole drug interactions.

What are the common drug interactions of Enablex and Fluconazole, by gender? *:

female:

Diarrhoea
Renal tubular necrosis (death of kidney tubules)
Vomiting
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nausea (feeling of having an urge to vomit)
Osteoporosis (bones weak and more likely to break)
Pain
Abasia (inability to walk)
Angina pectoris (chest pain due to ischemia of the heart muscle)

male:

Chronic kidney disease
Diarrhoea
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Necrosis ischaemic (death of cell due to lack of blood supply)
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)
Unresponsive to stimuli
Acidosis (build-up of carbon dioxide in the blood)
Brain hypoxia (reduced supply of oxygen to the brain)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)

What are the common drug interactions of Enablex and Fluconazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Ankylosing spondylitis (type of arthritis affecting the spine)
Somnolence (a state of near-sleep, a strong desire for sleep)

30-39:

Arterial thrombosis (formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system)
Cardiac valve vegetation (heart valve abnormal growth)
Drug ineffective
Pathogen resistance

40-49:

Urinary tract infection
Chronic kidney disease
Lymphocyte count increased
Monocyte count increased
Proteus test positive
Streptococcal urinary tract infection (a bacterial infection of urinary tract)
White blood cell count increased
Anxiety
Arachnoiditis (neuropathic disease caused by inflammation of the arachnoid)
Arthralgia (joint pain)

50-59:

Bone disorder
Calcium deficiency (lack of calcium)
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body)
Depression
Diarrhoea
Disturbance in attention
Dizziness
Fall
Multiple fractures
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)

60+:

Chronic kidney disease
Renal failure (kidney dysfunction)
Peripheral vascular disorder
Renal failure acute (rapid kidney dysfunction)
Acute myocardial infarction (acute heart attack)
Disseminated intravascular coagulation (systemic activation of blood coagulation)
Necrosis ischaemic (death of cell due to lack of blood supply)
Pain
Pneumonia
Respiratory failure (inadequate gas exchange by the respiratory system)

What are the existing conditions these people have? *

Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 26 people, 53.06%
Pain: 16 people, 32.65%
High Blood Pressure: 15 people, 30.61%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 14 people, 28.57%
High Blood Cholesterol: 13 people, 26.53%
Infection: 12 people, 24.49%
Stress And Anxiety: 8 people, 16.33%
Depression: 8 people, 16.33%
Inflammation: 7 people, 14.29%
Fluid Retention (an abnormal accumulation of fluid in the blood): 7 people, 14.29%

* Approximation only. Some reports may have incomplete information.

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