Enablex and Januvia drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Enablex (darifenacin hydrobromide) and Januvia (sitagliptin phosphate). Common drug interactions include fall among females and renal failure among males.

The phase IV clinical study analyzes what interactions people have when they take Enablex and Januvia. It is created by eHealthMe based on reports of 56 people who take the same drugs from the FDA, and is updated regularly.

What is Enablex?

Enablex has active ingredients of darifenacin hydrobromide. It is often used in urge incontinence. eHealthMe is studying from 4,934 Enablex users. Check the latest studies of Enablex.

What is Januvia?

Januvia has active ingredients of sitagliptin phosphate. It is often used in diabetes. eHealthMe is studying from 72,818 Januvia users. Check the latest studies of Januvia.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 27, 2026

56 people who take Enablex and Januvia together, and have interactions are studied.

What are the common drug interactions of Enablex and Januvia, by gender? *:

female:

Fall
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hypoaesthesia (reduced sense of touch or sensation)
Multiple sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath)
Nephrogenic anaemia (anaemia due to kidney disease)
Sinusitis (inflammation of sinus)
Asthenia (weakness)
Asthma
Balance disorder
Chest pain

male:

Renal failure (kidney dysfunction)
Nausea (feeling of having an urge to vomit)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dizziness
Dyspepsia (indigestion)
Fluid overload (too much fluid in the blood)
Haematocrit decreased
Loss of consciousness
Malignant hypertension (a hypertensive emergency is a condition in which elevated blood pressure results in target organ damage)

What are the common drug interactions of Enablex and Januvia, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Ill-defined disorder
Depression
Suicide attempt

40-49:

Skin disorder (skin disease)
Vomiting
Weight decreased
Abdominal discomfort
Application site ulcer
Asthenia (weakness)
Back pain
Blood glucose increased
Chest discomfort
Diarrhoea

50-59:

Abdominal pain
Back pain
Decreased appetite
Diarrhoea
Myalgia (muscle pain)
Arthralgia (joint pain)
Asthenia (weakness)
Balance disorder
Drug ineffective
Dyspnoea (difficult or laboured respiration)

60+:

Renal failure (kidney dysfunction)
Pneumonia
Cardiac failure congestive
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Deep vein thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis)
Dizziness
Dyspepsia (indigestion)
Fluid overload (too much fluid in the blood)
Haematocrit decreased
Loss of consciousness

What are the existing conditions these people have? *

Pain: 11 people, 19.64%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 10 people, 17.86%
Type 2 Diabetes: 8 people, 14.29%
High Blood Cholesterol: 7 people, 12.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 12.50%
Headache (pain in head): 5 people, 8.93%
Urinary Tract Infection: 4 people, 7.14%
Insomnia (sleeplessness): 4 people, 7.14%
Gastrointestinal Disorder (functional problems of gastrointestinal tract): 4 people, 7.14%
Gastric Ulcer (stomach ulcer): 4 people, 7.14%

* Approximation only. Some reports may have incomplete information.

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