Enbrel and Amevive drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Enbrel (etanercept) and Amevive (alefacept). Common drug interactions include acne among females and gastric polyps among males.

The phase IV clinical study analyzes what interactions people have when they take Enbrel and Amevive. It is created by eHealthMe based on reports of 88 people who take the same drugs from the FDA, and is updated regularly.

What is Enbrel?

Enbrel has active ingredients of etanercept. It is often used in rheumatoid arthritis. eHealthMe is studying from 664,678 Enbrel users. Check the latest studies of Enbrel.

What is Amevive?

Amevive has active ingredients of alefacept. It is often used in psoriasis. eHealthMe is studying from 3,812 Amevive users. Check the latest studies of Amevive.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

88 people who take Enbrel and Amevive together, and have interactions are studied.

What are the common drug interactions of Enbrel and Amevive, by gender? *:

female:

Acne (skin problems that cause pimples)
Dysuria (painful or difficult urination)
Erythema (redness of the skin)
Haematuria (presence of blood in urine)
Incontinence (lack of moderation or self-control)
Neutropenia (an abnormally low number of neutrophils)
Pain
Papule
Pyrexia (fever)
Blood pressure increased

male:

Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)
Sensation of foreign body
Muscle cramp (painful sensation caused by muscle contraction)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Rib fracture
Actinic keratosis (skin disease due to sun exposure)
Application site erythema (redness of the skin at application site)
Blood cholesterol increased
Burning sensation
Cough

What are the common drug interactions of Enbrel and Amevive, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Drug ineffective
Bacterial infection
Viral infection

10-19:

n/a

20-29:

Abdominal pain
Acne (skin problems that cause pimples)
Dysuria (painful or difficult urination)
Erythema (redness of the skin)
Haematuria (presence of blood in urine)
Incontinence (lack of moderation or self-control)
Neutropenia (an abnormally low number of neutrophils)
Papule
Pyrexia (fever)
Arthropathy

30-39:

Cellulitis (infection under the skin)
Chest pain
Muscle spasms (muscle contraction)
Myalgia (muscle pain)
Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow))
Cd4 lymphocytes decreased
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Headache (pain in head)
Hyperlipidaemia (presence of excess lipids in the blood)
Influenza like illness

40-49:

Gastric polyps (abnormal growth of stomach tissue projecting from a mucous membrane)
Sensation of foreign body
Gastric disorder (disease of stomach)
Skin lesion
Drug ineffective
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Pruritus (severe itching of the skin)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Haemoglobin decreased
Pain

50-59:

Dyspnoea (difficult or laboured respiration)
Pruritus (severe itching of the skin)
Discomfort
Gait disturbance
Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels)
Nasopharyngitis (inflammation of the nasopharynx)
Pulmonary hypertension (increase in blood pressure in the lung artery)
Sciatic nerve neuropathy (sciatic nerve damage)
Sleep apnoea syndrome (a sleep-related disorder in which the effort to breathe is diminished or absent)
Stress

60+:

Cd4 lymphocytes decreased
Headache (pain in head)
Breath sounds
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
Cerebrovascular disorder (disease of brain)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Death
Diabetes mellitus (diabetes, caused by a deficiency of the pancreatic hormone insulin)
Drug ineffective
Dystrophic calcification (calcification occurring in degenerated or necrotic tissue)

What are the existing conditions these people have? *

Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 5 people, 5.68%

* Approximation only. Some reports may have incomplete information.

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