Enbrel and Dilantin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Enbrel (etanercept) and Dilantin (phenytoin sodium). Common drug interactions include pharyngeal disorder among females and myocardial infarction among males.

The phase IV clinical study analyzes what interactions people have when they take Enbrel and Dilantin. It is created by eHealthMe based on reports of 66 people who take the same drugs from the FDA, and is updated regularly.

What is Enbrel?

Enbrel has active ingredients of etanercept. It is often used in rheumatoid arthritis. eHealthMe is studying from 664,678 Enbrel users. Check the latest studies of Enbrel.

What is Dilantin?

Dilantin has active ingredients of phenytoin sodium. It is often used in epilepsy. eHealthMe is studying from 20,858 Dilantin users. Check the latest studies of Dilantin.

On Jul, 08, 2026

66 people who take Enbrel and Dilantin together, and have interactions are studied.

What are the common drug interactions of Enbrel and Dilantin, by gender? *:

female:

Pharyngeal disorder
Pneumonia
Pyrexia (fever)
Spinal pain (pain in spine)
Aggression
Belligerence (aggressive or warlike behaviour)
Benign intracranial hypertension (benign intracranial hypertension (bih) is a headache syndrome)
Coma (state of unconsciousness lasting more than six hours)
Eye burns
Headache (pain in head)

male:

Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Incision site haematoma (small sac of blood near a surgical site)
Oedema peripheral (superficial swelling)
Peripheral vascular disorder
Platelet count decreased
Renal failure acute (rapid kidney dysfunction)
Tongue haemorrhage (bleeding from tongue)
Ventricular fibrillation (abnormally irregular heart rhythm)
Ventricular tachycardia (rapid heartbeat that originates in one of the lower chambers (the ventricles) of the heart)

What are the common drug interactions of Enbrel and Dilantin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Balance disorder
Blood sodium increased
Constipation
Death
Disease progression
Gait disturbance
Gestational hypertension (elevated blood pressure during pregnancy)
Injection site urticaria (rash of round, red welts on the skin at injection site)
Migraine (headache)
Nasopharyngitis (inflammation of the nasopharynx)

40-49:

Cellulitis (infection under the skin)
Hypoaesthesia (reduced sense of touch or sensation)
Nephrolithiasis (calculi in the kidneys)
Skin exfoliation (removal of the oldest dead skin cells)
Tendon disorder (disease of tendon)
Therapeutic response decreased (less preventive response)
Application site pruritus (application site severe itching of the skin)
Application site reaction
Application site scab (hard coating on the skin formed at application site)
Benign neoplasm (benign (non-cancerous) tumour)

50-59:

Osteoporosis (bones weak and more likely to break)
Pain
Pleural effusion (water on the lungs)
Pneumonia
Spinal fracture (fracture in one of vertebrae)
Subarachnoid haemorrhage (blood leaks into the space between two membranes that surround the brain)
Vitamin d deficiency
Wheezing (a high-pitched whistling sound made while you breath)
White blood cell count decreased
Rash

60+:

Cough
Joint swelling
Malaise (a feeling of general discomfort or uneasiness)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pain
Arthralgia (joint pain)
Adverse reaction
Aortic stenosis (obstruction to the outflow of blood from the left ventricle into the aorta)
Benign prostatic hyperplasia (benign enlargement of the prostate)
Blood cholesterol increased

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 8 people, 12.12%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 7 people, 10.61%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 6 people, 9.09%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 5 people, 7.58%

* Approximation only. Some reports may have incomplete information.

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