Enbrel and Eplerenone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Enbrel (etanercept) and Eplerenone (eplerenone). Common drug interactions include pain in extremity among females and pain in extremity among males.

The phase IV clinical study analyzes what interactions people have when they take Enbrel and Eplerenone. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Enbrel?

Enbrel has active ingredients of etanercept. It is often used in rheumatoid arthritis. eHealthMe is studying from 664,678 Enbrel users. Check the latest studies of Enbrel.

What is Eplerenone?

Eplerenone has active ingredients of eplerenone. It is often used in high blood pressure. eHealthMe is studying from 9,979 Eplerenone users. Check the latest studies of Eplerenone.

On Aug, 01, 2026

26 people who take Enbrel and Eplerenone together, and have interactions are studied.

Enbrel and Eplerenone drug interactions.

What are the common drug interactions of Enbrel and Eplerenone, by gender? *:

female:

Pain in extremity
Arthralgia (joint pain)
Atrioventricular block complete (heart block complete)
Drug ineffective
Alopecia (absence of hair from areas of the body)
Cardiac aneurysm (a condition that can occur after a myocardial infarction due to the inadequate resistance of the new scar tissue to the systolic pressure)
Cardiac failure
Colon adenoma (non cancerous epithelial colon tumour having a glandular origin and structure)
Coronary artery disease (plaque building up along the inner walls of the arteries of the heart, which narrows the arteries and restricts blood flow to the heart)
Ejection fraction decreased (systolic heart failure)

male:

Pain in extremity
Arthralgia (joint pain)
Angiopathy (generic term for a disease of the blood vessels)
Anxiety
Bedridden
Cellulitis (infection under the skin)
Crying
Discomfort
Emotional distress
Erythema (redness of the skin)

What are the common drug interactions of Enbrel and Eplerenone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Abdominal pain
Arthralgia (joint pain)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Fall
Haematochezia (passage of stools containing blood)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Hepatic steatosis (fatty liver disease)
Hernia (hernia happens when part of an internal organ or tissue bulges through a weak area of muscle)
Hydronephrosis (water inside the kidney)
Kidney small

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Arthralgia (joint pain)
Pain in extremity
Peripheral swelling
Abdominal discomfort
Diarrhoea
Fatigue (feeling of tiredness)
Somnolence (a state of near-sleep, a strong desire for sleep)
Muscle spasms (muscle contraction)
Abdominal pain upper
Gastrointestinal disorder (functional problems of gastrointestinal tract)

60+:

Pain in extremity
Atrioventricular block complete (heart block complete)
Ischaemic cardiomyopathy (weakness in the muscle of the heart due to inadequate oxygen delivery to the myocardium with coronary artery disease)
Peripheral swelling
Arthralgia (joint pain)
Blood sodium decreased
Muscle spasms (muscle contraction)
Weight increased
Drug ineffective
Alopecia (absence of hair from areas of the body)

What are the existing conditions these people have? *

Acromegaly (body produces too much growth hormone, leading to excess growth of body tissues): 6 people, 23.08%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 5 people, 19.23%
Adrenal Insufficiency (a condition in which the adrenal glands do not produce adequate amounts of steroids): 4 people, 15.38%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 7.69%
High Blood Cholesterol: 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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