Enbrel and Gemcitabine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Enbrel (etanercept) and Gemcitabine (gemcitabine). Common drug interactions include hepatotoxicity among females and thrombocytopenia among males.

The phase IV clinical study analyzes what interactions people have when they take Enbrel and Gemcitabine. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Enbrel?

Enbrel has active ingredients of etanercept. It is often used in rheumatoid arthritis. eHealthMe is studying from 664,678 Enbrel users. Check the latest studies of Enbrel.

What is Gemcitabine?

Gemcitabine has active ingredients of gemcitabine. eHealthMe is studying from 31,337 Gemcitabine users. Check the latest studies of Gemcitabine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

13 people who take Enbrel and Gemcitabine together, and have interactions are studied.

Enbrel and Gemcitabine drug interactions.

What are the common drug interactions of Enbrel and Gemcitabine, by gender? *:

female:

Hepatotoxicity (chemical-driven liver damage)
Neutropenia (an abnormally low number of neutrophils)
Thrombocytopenia (decrease of platelets in blood)
Fall
Lumbar vertebral fracture
Death
Injection site pruritus (severe itching at injection site)
Injection site rash
Metastases to liver (cancer spreads to liver)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

male:

Thrombocytopenia (decrease of platelets in blood)
Anaemia (lack of blood)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)
Lymphadenopathy (disease or enlargement of lymph nodes)
Lymphatic obstruction (blockage in lymphatic duct)
Pleural effusion (water on the lungs)
Renal failure acute (rapid kidney dysfunction)
Sepsis (a severe blood infection that can lead to organ failure and death)
Urinary tract infection staphylococcal
Lung neoplasm malignant (cancer tumour of lung)

What are the common drug interactions of Enbrel and Gemcitabine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Diarrhoea
Gastrointestinal toxicity (damage to digestive tract by any substance)
Infection
Mucosal inflammation (infection of mucous membrane)
Nausea (feeling of having an urge to vomit)
Vomiting
Death
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Pre-eclampsia (high blood pressure and significant amounts of protein in the urine of a pregnant woman)
Pulmonary embolism (blockage of the main artery of the lung)

40-49:

Thrombocytopenia (decrease of platelets in blood)
Anaemia (lack of blood)
Cellulitis (infection under the skin)
Dehydration (dryness resulting from the removal of water)
Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
Hiatus hernia (hernia resulting from the protrusion of part of the stomach through the diaphragm)
Hydronephrosis (water inside the kidney)
Hypokalaemia (low potassium)
Hypomagnesaemia (electrolyte disturbance in which there is an abnormally low level of magnesium in the blood)
Hypophosphataemia (electrolyte disturbance in which there is an abnormally low level of phosphate in the blood)

50-59:

Hepatotoxicity (chemical-driven liver damage)
Neutropenia (an abnormally low number of neutrophils)
Thrombocytopenia (decrease of platelets in blood)
Diarrhoea
Fall
Hypotension (abnormally low blood pressure)
Psoriatic arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop)
Respiratory failure (inadequate gas exchange by the respiratory system)
Rotator cuff syndrome (a spectrum of conditions affecting the rotator cuff tendons of the shoulder)
Injection site pruritus (severe itching at injection site)

60+:

Lung neoplasm malignant (cancer tumour of lung)
Tuberculosis (a bacterial infection by mycobacterium tuberculosis)
Brain neoplasm malignant (brain cancer tumour)
Bruxism (habitual grinding of the teeth, typically during sleep)
Cholelithiasis (the presence or formation of gallstones in the gallbladder or bile ducts)
Constipation
Deformity (disfigurement)
Emotional distress
Erectile dysfunction
Exostosis (formation of new bone on the surface of a bone)

What are the existing conditions these people have? *

Psoriasis (immune-mediated disease that affects the skin): 3 people, 23.08%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 2 people, 15.38%
Rhabdomyosarcoma (cancer of the bone, soft tissues, or connective tissue (e.g., tendon or cartilage)): 1 person, 7.69%
High Blood Cholesterol: 1 person, 7.69%
Colon Cancer: 1 person, 7.69%
Deep Venous Thrombosis (blood clot in a major vein that usually develops in the legs and/or pelvis): 1 person, 7.69%
Diabetes: 1 person, 7.69%
Endometrial Sarcoma (cancer of uterus): 1 person, 7.69%
Hepatic Neoplasm Malignant (liver cancer): 1 person, 7.69%
Lung Cancer - Non-Small Cell (lung cancer): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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