Enbrel and Phoslo drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Enbrel (etanercept) and Phoslo (calcium acetate). Common drug interactions include injection site pain among females and musculoskeletal stiffness among males.

The phase IV clinical study analyzes what interactions people have when they take Enbrel and Phoslo. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Enbrel?

Enbrel has active ingredients of etanercept. It is often used in rheumatoid arthritis. eHealthMe is studying from 664,678 Enbrel users. Check the latest studies of Enbrel.

What is Phoslo?

Phoslo has active ingredients of calcium acetate. eHealthMe is studying from 4,291 Phoslo users. Check the latest studies of Phoslo.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

15 people who take Enbrel and Phoslo together, and have interactions are studied.

What are the common drug interactions of Enbrel and Phoslo, by gender? *:

female:

Injection site pain
Injection site pruritus (severe itching at injection site)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Oedema peripheral (superficial swelling)
Rash
Scar
Skin hypertrophy (skin cells enlarges)
Skin hypopigmentation (loss of skin colour)
Skin induration (an abnormally hard spot or area on the skin)
Skin plaque (red, scaly patches to appear on the skin)

male:

Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Gait disturbance
Pleural fibrosis (formation of fibrous tissue in lung)
Rash
Skin hyperpigmentation (disorders affect the colour of your skin)
Scleroderma (hard skin)
Subcutaneous nodule
Anxiety
Depression

What are the common drug interactions of Enbrel and Phoslo, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Anxiety
Depression
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Arthralgia (joint pain)
Asthenia (weakness)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Deformity (disfigurement)
Dry skin
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters)
Fatigue (feeling of tiredness)

40-49:

Drug ineffective
Dry skin
Emotional distress
Ephelides (tanned macules found on the skin)
Extremity contracture (permanent shortening of a muscle or joint of arms and legs)
General physical health deterioration (weak health status)
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Infection
Injury
Joint contracture (a permanent shortening of a muscle or joint)

50-59:

Arthralgia (joint pain)
Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves)
Pain
Erythema (redness of the skin)
Gait disturbance
Hypoaesthesia (reduced sense of touch or sensation)
Mobility decreased (ability to move is reduced)
Nephrogenic systemic fibrosis (involves fibrosis of skin, joints, eyes due to kidney disease)
Pleural fibrosis (formation of fibrous tissue in lung)
Rash

60+:

Pain
Dry skin
Scar
Skin hypertrophy (skin cells enlarges)
Skin hypopigmentation (loss of skin colour)
Skin induration (an abnormally hard spot or area on the skin)
Skin plaque (red, scaly patches to appear on the skin)
Skin tightness
Swelling
Tooth fracture

What are the existing conditions these people have? *

Nuclear Magnetic Resonance Imaging Brain: 6 people, 40.00%
Psoriasis (immune-mediated disease that affects the skin): 4 people, 26.67%
Nuclear Magnetic Resonance Imaging Abdominal: 3 people, 20.00%
Pain: 2 people, 13.33%
High Blood Pressure: 2 people, 13.33%
Confusion: 1 person, 6.67%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 6.67%
Cough: 1 person, 6.67%
Depression: 1 person, 6.67%
Calcium Deficiency (lack of calcium): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Enbrel and Phoslo?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously