Enbrel and Uptravi drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Enbrel (etanercept) and Uptravi (selexipag). Common drug interactions include headache among females.

The phase IV clinical study analyzes what interactions people have when they take Enbrel and Uptravi. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Enbrel?

Enbrel has active ingredients of etanercept. It is often used in rheumatoid arthritis. eHealthMe is studying from 664,678 Enbrel users. Check the latest studies of Enbrel.

What is Uptravi?

Uptravi has active ingredients of selexipag. eHealthMe is studying from 26,576 Uptravi users. Check the latest studies of Uptravi.

On Jul, 24, 2026

17 people who take Enbrel and Uptravi together, and have interactions are studied.

What are the common drug interactions of Enbrel and Uptravi, by gender? *:

female:

Headache (pain in head)
Dyspnoea (difficult or laboured respiration)
Arthralgia (joint pain)
Back pain
Fatigue (feeling of tiredness)
Gait disturbance
Pain
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Incontinence (lack of moderation or self-control)
Neck pain

male:

n/a

What are the common drug interactions of Enbrel and Uptravi, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Chest pain
Decreased appetite
Dizziness
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Fluid overload (too much fluid in the blood)
Gait disturbance
Nausea (feeling of having an urge to vomit)
Pain
Pulmonary arterial hypertension (high blood pressure in the arteries of lungs)

30-39:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)

40-49:

n/a

50-59:

Arthralgia (joint pain)
Headache (pain in head)
Arthritis (form of joint disorder that involves inflammation of one or more joints)
Back pain
Incontinence (lack of moderation or self-control)
Nausea (feeling of having an urge to vomit)
Neck pain
Pain in jaw
Pulmonary oedema (fluid accumulation in the lungs)
Dyspnoea (difficult or laboured respiration)

60+:

Headache (pain in head)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Urine abnormality
Lung disorder (lung disease)
Ear pain
Pain in jaw
Asthma
Atelectasis (partial or complete collapse of the lung)
Constipation
Dizziness

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 10 people, 58.82%
Stress And Anxiety: 4 people, 23.53%
Pulmonary Hypertension (increase in blood pressure in the lung artery): 4 people, 23.53%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 4 people, 23.53%
Pain: 4 people, 23.53%
Muscle Spasms (muscle contraction): 4 people, 23.53%
Cough: 4 people, 23.53%
Psoriasis (immune-mediated disease that affects the skin): 3 people, 17.65%
Systemic Lupus Erythematosus (an autoimmune disease, which means the body's immune system mistakenly, attacks healthy tissue): 3 people, 17.65%
Urination - Excessive Volume: 2 people, 11.76%

* Approximation only. Some reports may have incomplete information.

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