Endep and Aldactone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Endep (amitriptyline hydrochloride) and Aldactone (spironolactone). Common drug interactions include abdominal pain among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Endep and Aldactone. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Endep?

Endep has active ingredients of amitriptyline hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 1,302 Endep users. Check the latest studies of Endep.

What is Aldactone?

Aldactone has active ingredients of spironolactone. It is often used in acne. eHealthMe is studying from 46,063 Aldactone users. Check the latest studies of Aldactone.

On Aug, 05, 2026

13 people who take Endep and Aldactone together, and have interactions are studied.

What are the common drug interactions of Endep and Aldactone, by gender? *:

female:

Abdominal pain
Back pain
Blood urea nitrogen/creatinine ratio increased
Confusional state
Epistaxis (bleed from the nose)
Gamma-glutamyltransferase increased
Gastroenteritis (inflammation of stomach and intestine)
Haematochezia (passage of stools containing blood)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Headache (pain in head)

male:

Anaemia (lack of blood)
Dyspnoea (difficult or laboured respiration)
Surgery
Tricuspid valve incompetence (inefficient heart valve)
Weight decreased
Oedema peripheral (superficial swelling)
Alcohol problem
Cardiac failure
Encephalopathy (functioning of the brain is affected by some agent or condition)
Mitral valve incompetence (inefficient heart valve)

What are the common drug interactions of Endep and Aldactone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Epistaxis (bleed from the nose)
Haematochezia (passage of stools containing blood)
Haemorrhoids (a swollen vein or group of veins in the region of the anus)
Inflammation
Irritable bowel syndrome
Overweight
Rash
Vaginal haemorrhage (vaginal bleeding)
Haemorrhage (bleeding)
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Abdominal pain
Back pain
Anaemia (lack of blood)
Breast cancer
Cardiovascular disorder (heart diseases)
Coronary artery bypass
Cough
Disease recurrence
Drug withdrawal syndrome (interfere with normal social, occupational, or other functioning. are not due to another medical condition, drug use, or discontinuation)
Dyspnoea (difficult or laboured respiration)

What are the existing conditions these people have? *

Joint Pain: 4 people, 30.77%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 3 people, 23.08%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 3 people, 23.08%
Ankylosing Spondylitis (type of arthritis affecting the spine): 2 people, 15.38%
Cardiac Failure: 2 people, 15.38%
Cardiomyopathy (weakening of the heart muscle): 2 people, 15.38%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 2 people, 15.38%
Constipation: 2 people, 15.38%
Discomfort: 2 people, 15.38%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 15.38%

* Approximation only. Some reports may have incomplete information.

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