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Endep and Ibu drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Endep (amitriptyline hydrochloride) and Ibu (ibuprofen). Common drug interactions include constipation among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Endep and Ibu. It is created by eHealthMe based on reports of 21 people who take the same drugs from the FDA, and is updated regularly.

What is Endep?

Endep has active ingredients of amitriptyline hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 1,302 Endep users. Check the latest studies of Endep.

What is Ibu?

Ibu has active ingredients of ibuprofen. It is often used in pain. eHealthMe is studying from 246,531 Ibu users. Check the latest studies of Ibu.

On Jul, 25, 2026

21 people who take Endep and Ibu together, and have interactions are studied.

Endep and Ibu drug interactions.

What are the common drug interactions of Endep and Ibu, by gender? *:

female:

  1. Constipation
  2. Decreased appetite
  3. Diarrhoea
  4. Fatigue (feeling of tiredness)
  5. Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
  6. Flushing (the warm, red condition of human skin)
  7. Haematuria (presence of blood in urine)
  8. Hypoaesthesia (reduced sense of touch or sensation)
  9. Hypotension (abnormally low blood pressure)
  10. Limb discomfort (discomfort in leg)

male:

  1. Death
  2. Drug abuse
  3. Drug dependence

What are the common drug interactions of Endep and Ibu, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Dizziness
  2. Urinary tract infection
  3. Albumin urine present
  4. Constipation
  5. Decreased appetite
  6. Diarrhoea
  7. Fatigue (feeling of tiredness)
  8. Flank pain (a distressing sensation experienced around the lower back and the upper abdomen)
  9. Flushing (the warm, red condition of human skin)
  10. Haematuria (presence of blood in urine)

40-49:

  1. Anger
  2. Dyspnoea (difficult or laboured respiration)
  3. Mobility decreased (ability to move is reduced)
  4. Weight increased

50-59:

n/a

60+:

  1. Alanine aminotransferase increased
  2. Aspartate aminotransferase increased

What are the existing conditions these people have? *

  1. Migraine (headache): 14 people, 66.67%
  2. Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 13 people, 61.90%
  3. Oral Candidiasis (fungal infection of mouth): 7 people, 33.33%
  4. Neuralgia (pain in one or more nerves): 7 people, 33.33%
  5. Flank Pain (a distressing sensation experienced around the lower back and the upper abdomen): 7 people, 33.33%
  6. Back Pain: 7 people, 33.33%
  7. Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 4 people, 19.05%

* Approximation only. Some reports may have incomplete information.

Do you take Endep and Ibu?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Endep and Ibu:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Endep:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Ibu:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Endep and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Ibu and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on amitriptyline hydrochloride and ibuprofen (the active ingredients of Endep and Ibu, respectively), and Endep and Ibu (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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