Endep and Leflunomide drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Endep (amitriptyline hydrochloride) and Leflunomide (leflunomide). Common drug interactions include arthralgia among females and blindness unilateral among males.

The phase IV clinical study analyzes what interactions people have when they take Endep and Leflunomide. It is created by eHealthMe based on reports of 13 people who take the same drugs from the FDA, and is updated regularly.

What is Endep?

Endep has active ingredients of amitriptyline hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 1,302 Endep users. Check the latest studies of Endep.

What is Leflunomide?

Leflunomide has active ingredients of leflunomide. It is often used in rheumatoid arthritis. eHealthMe is studying from 82,105 Leflunomide users. Check the latest studies of Leflunomide.

On Jul, 07, 2026

13 people who take Endep and Leflunomide together, and have interactions are studied.

Endep and Leflunomide drug interactions.

What are the common drug interactions of Endep and Leflunomide, by gender? *:

female:

Arthralgia (joint pain)
Diarrhoea
Hypertension (high blood pressure)
Urticaria (rash of round, red welts on the skin that itch intensely)
Apathy
Asthenia (weakness)
Burning feet syndrome (burning sensation in the sole of the foot)
Confusional state
Conjunctivitis (pink eye)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)

male:

Blindness unilateral
Body mass index increased
Thyroid disorder (thyroid diseases)
Weight decreased
Diarrhoea
Fatigue (feeling of tiredness)
Hyperhidrosis (abnormally increased sweating)
Hypoaesthesia (reduced sense of touch or sensation)
Pain in extremity
Psychiatric symptom

What are the common drug interactions of Endep and Leflunomide, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Apathy
Arthralgia (joint pain)
Asthenia (weakness)
Burning feet syndrome (burning sensation in the sole of the foot)
Confusional state
Conjunctivitis (pink eye)
Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
Diarrhoea
Haematuria (presence of blood in urine)
Hypertension (high blood pressure)

50-59:

Blindness unilateral
Body mass index increased
Diarrhoea
Fatigue (feeling of tiredness)
Hyperhidrosis (abnormally increased sweating)
Hypoaesthesia (reduced sense of touch or sensation)
Pain in extremity
Psychiatric symptom
Pyrexia (fever)
Renal impairment (severely reduced kidney function)

60+:

Arthralgia (joint pain)
Back pain
Oral pain
Pain in extremity
Pneumonia cytomegaloviral (cmv pneumonia is caused by a member of a group of herpes-type viruses)
Pneumonia pseudomonal (pseudomonas pneumonia is an infection caused by the microbe known as pseudomonas aeruginosa)
Poor quality sleep
Red cell distribution width increased
Renal impairment (severely reduced kidney function)
Vision blurred

What are the existing conditions these people have? *

Cryoglobulinaemia (blood contains large amounts of cryoglobulins - proteins): 4 people, 30.77%
Insomnia (sleeplessness): 2 people, 15.38%
Depression: 2 people, 15.38%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 15.38%
Osteoporosis (bones weak and more likely to break): 2 people, 15.38%
Vitamin B12 Deficiency: 1 person, 7.69%
Asthma: 1 person, 7.69%
Atrophy (wasting away of a part of the body): 1 person, 7.69%
Constipation: 1 person, 7.69%
Fluid Retention (an abnormal accumulation of fluid in the blood): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

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