Endep and Metronidazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Endep (amitriptyline hydrochloride) and Metronidazole (metronidazole). Common drug interactions include febrile neutropenia among females and diverticular perforation among males.

The phase IV clinical study analyzes what interactions people have when they take Endep and Metronidazole. It is created by eHealthMe based on reports of 11 people who take the same drugs from the FDA, and is updated regularly.

What is Endep?

Endep has active ingredients of amitriptyline hydrochloride. It is often used in fibromyalgia. eHealthMe is studying from 1,302 Endep users. Check the latest studies of Endep.

What is Metronidazole?

Metronidazole has active ingredients of metronidazole. It is often used in vaginitis bacterial. eHealthMe is studying from 59,578 Metronidazole users. Check the latest studies of Metronidazole.

On Jul, 05, 2026

11 people who take Endep and Metronidazole together, and have interactions are studied.

Endep and Metronidazole drug interactions.

What are the common drug interactions of Endep and Metronidazole, by gender? *:

female:

Febrile neutropenia (fever with reduced white blood cells)
Mucosal inflammation (infection of mucous membrane)
Pyrexia (fever)

male:

Diverticular perforation (serious gastrointestinal condition in which the intestine's walls are perforated)
Oral candidiasis (fungal infection of mouth)
Oral herpes (viral infection of mouth)
Oral infection
Febrile neutropenia (fever with reduced white blood cells)
Diarrhoea

What are the common drug interactions of Endep and Metronidazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

n/a

60+:

Diverticular perforation (serious gastrointestinal condition in which the intestine's walls are perforated)
Oral candidiasis (fungal infection of mouth)
Oral herpes (viral infection of mouth)
Febrile neutropenia (fever with reduced white blood cells)
Oral infection
Diarrhoea
Mucosal inflammation (infection of mucous membrane)
Pyrexia (fever)

What are the existing conditions these people have? *

Back Pain: 10 people, 90.91%
Upper Respiratory Tract Infection: 7 people, 63.64%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 63.64%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 63.64%
Constipation: 7 people, 63.64%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 7 people, 63.64%
Nausea (feeling of having an urge to vomit): 7 people, 63.64%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 7 people, 63.64%
Enlarged Prostate: 6 people, 54.55%
Febrile Neutropenia (fever with reduced white blood cells): 6 people, 54.55%

* Approximation only. Some reports may have incomplete information.

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