1. Home
  2. Analysis
  3. Entecavir
  4. Epclusa

Entecavir and Epclusa drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Entecavir (entecavir) and Epclusa (sofosbuvir; velpatasvir). Common drug interactions include drug ineffective among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Entecavir and Epclusa. It is created by eHealthMe based on reports of 16 people who take the same drugs from the FDA, and is updated regularly.

What is Entecavir?

Entecavir has active ingredients of entecavir. It is often used in hepatitis b. eHealthMe is studying from 7,354 Entecavir users. Check the latest studies of Entecavir.

What is Epclusa?

Epclusa has active ingredients of sofosbuvir; velpatasvir. eHealthMe is studying from 12,120 Epclusa users. Check the latest studies of Epclusa.

On Jul, 19, 2026

16 people who take Entecavir and Epclusa together, and have interactions are studied.

Entecavir and Epclusa drug interactions.

What are the common drug interactions of Entecavir and Epclusa, by gender? *:

female:

  1. Drug ineffective
  2. Hepatitis c
  3. Abdominal discomfort
  4. Arthralgia (joint pain)
  5. Back pain
  6. Blood fibrinogen decreased
  7. Cardiorenal syndrome (kidney failure and heart failure)
  8. Cryoglobulinaemia (blood contains large amounts of cryoglobulins - proteins)
  9. Diarrhoea
  10. Diastolic dysfunction

male:

  1. Death
  2. Hepatitis c rna increased
  3. Mood swings (an extreme or rapid change in mood)
  4. Hepatitis c virus test positive
  5. Abdominal pain upper
  6. Anxiety
  7. Drug ineffective
  8. Fall
  9. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  10. Hepatitis c

What are the common drug interactions of Entecavir and Epclusa, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Drug ineffective
  2. Hepatitis c
  3. Abdominal pain upper
  4. Fall
  5. Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
  6. Malaise (a feeling of general discomfort or uneasiness)

60+:

  1. Death
  2. Hepatitis c rna increased
  3. Influenza like illness
  4. Micturition urgency (urgency to pass the urine)
  5. Myalgia (muscle pain)
  6. Nausea (feeling of having an urge to vomit)
  7. Pyrexia (fever)
  8. Vomiting
  9. Hepatitis c virus test positive
  10. Abdominal discomfort

What are the existing conditions these people have? *

  1. Hepatitis C: 6 people, 37.50%
  2. Hepatitis Viral: 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Entecavir and Epclusa?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Entecavir and Epclusa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Entecavir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Epclusa:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Entecavir and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Epclusa and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on entecavir and sofosbuvir; velpatasvir (the active ingredients of Entecavir and Epclusa, respectively), and Entecavir and Epclusa (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

Recent studies on eHealthMe:

© 2026 eHealthMe.com. All rights reserved. Use of this site constitutes acceptance of eHealthMe.com's terms of service and privacy policy.