Entecavir and Sofosbuvir drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Entecavir (entecavir) and Sofosbuvir (sofosbuvir). Common drug interactions include hepatic enzyme increased among females and hepatic fibrosis among males.

The phase IV clinical study analyzes what interactions people have when they take Entecavir and Sofosbuvir. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Entecavir?

Entecavir has active ingredients of entecavir. It is often used in hepatitis b. eHealthMe is studying from 7,354 Entecavir users. Check the latest studies of Entecavir.

What is Sofosbuvir?

Sofosbuvir has active ingredients of sofosbuvir. eHealthMe is studying from 9,194 Sofosbuvir users. Check the latest studies of Sofosbuvir.

On Jul, 15, 2026

44 people who take Entecavir and Sofosbuvir together, and have interactions are studied.

Entecavir and Sofosbuvir drug interactions.

What are the common drug interactions of Entecavir and Sofosbuvir, by gender? *:

female:

Hepatic enzyme increased
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Drug resistance (reduction in effectiveness of a drug)
Hyperbilirubinaemia (excess of bilirubin in the blood)
Ascites (accumulation of fluid in the abdominal cavity)
Cardiomyopathy (weakening of the heart muscle)
Decreased appetite
Fatigue (feeling of tiredness)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)

male:

Hepatic fibrosis (scarring process that represents the liver's response to injury)
Nodular regenerative hyperplasia (regeneration of a skin condition characterized by crops of small, tender, erythematous nodules on the legs)
Ascites (accumulation of fluid in the abdominal cavity)
Biliary dilatation
Bronchial carcinoma (lung cancer)
Cell death
Cerebral haemorrhage (bleeding within the brain)
Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Constipation
Cryoglobulinaemia (blood contains large amounts of cryoglobulins - proteins)

What are the common drug interactions of Entecavir and Sofosbuvir, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Ascites (accumulation of fluid in the abdominal cavity)
Cerebral haemorrhage (bleeding within the brain)
Cryoglobulinaemia (blood contains large amounts of cryoglobulins - proteins)
Cytomegalovirus test positive
Encephalopathy (functioning of the brain is affected by some agent or condition)
Endocarditis (inflammation in heart muscle)
Enterobacter sepsis (sepsis due to bacteria of the family enterobacteriaceae)
Gastroenteritis cryptosporidial (inflammation of stomach and intestine caused by cryptosporidial infection)
Liver transplant
Lung disorder (lung disease)

50-59:

Cholestasis (a condition where bile cannot flow from the liver to the duodenum)
Hepatic enzyme increased
Ascites (accumulation of fluid in the abdominal cavity)
Biliary dilatation
Cardiomyopathy (weakening of the heart muscle)
Cell death
Decreased appetite
Fatigue (feeling of tiredness)
Hepatitis c
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)

60+:

Drug resistance (reduction in effectiveness of a drug)
Haemoglobin decreased
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Haematemesis (vomiting of blood)
Haematocrit decreased
Hepatic encephalopathy (spectrum of neuropsychiatric abnormalities in patients with liver failure)
Hepatic enzyme increased
Hepatic fibrosis (scarring process that represents the liver's response to injury)
Hepatitis b surface antigen positive

What are the existing conditions these people have? *

Hepatitis C: 16 people, 36.36%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 6 people, 13.64%
Cryoglobulinaemia (blood contains large amounts of cryoglobulins - proteins): 5 people, 11.36%
Immunodeficiency Disorders: 3 people, 6.82%
Diabetes: 3 people, 6.82%

* Approximation only. Some reports may have incomplete information.

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