Entresto and Caffeine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Entresto (sacubitril; valsartan) and Caffeine (caffeine). Common drug interactions include heart rate increased among females and burnout syndrome among males.

The phase IV clinical study analyzes what interactions people have when they take Entresto and Caffeine. It is created by eHealthMe based on reports of 15 people who take the same drugs from the FDA, and is updated regularly.

What is Entresto?

Entresto has active ingredients of sacubitril; valsartan. eHealthMe is studying from 126,629 Entresto users. Check the latest studies of Entresto.

What is Caffeine?

Caffeine has active ingredients of caffeine. It is often used in fatigue. eHealthMe is studying from 6,667 Caffeine users. Check the latest studies of Caffeine.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

15 people who take Entresto and Caffeine together, and have interactions are studied.

Entresto and Caffeine drug interactions.

What are the common drug interactions of Entresto and Caffeine, by gender? *:

female:

Heart rate increased
Fluid retention (an abnormal accumulation of fluid in the blood)
Hypoacusis (loss of hearing)
Hypokinesia (decreased bodily movement)
Insomnia (sleeplessness)
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Visual impairment
Weight decreased
Alopecia (absence of hair from areas of the body)
Asthenia (weakness)

male:

Burnout syndrome (problems related to life-management difficulty, but not considered a ""disorder)
Dyspnoea (difficult or laboured respiration)
Weight decreased
Cough
Fluid retention (an abnormal accumulation of fluid in the blood)
Weight fluctuation
Headache (pain in head)
Dizziness
Ejection fraction decreased (systolic heart failure)
Bone disorder

What are the common drug interactions of Entresto and Caffeine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Burnout syndrome (problems related to life-management difficulty, but not considered a ""disorder)
Dyspnoea (difficult or laboured respiration)
Cough
Fluid retention (an abnormal accumulation of fluid in the blood)
Weight fluctuation
Dizziness

50-59:

Cough
Headache (pain in head)
Renal impairment (severely reduced kidney function)
Weight fluctuation
Ejection fraction decreased (systolic heart failure)
Aspartate aminotransferase increased
Cardiac failure congestive
Dehydration (dryness resulting from the removal of water)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Hypertension (high blood pressure)

60+:

n/a

What are the existing conditions these people have? *

Cardiac Failure: 5 people, 33.33%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 3 people, 20.00%
Skin Blushing/flushing (a sudden reddening of the face, neck): 2 people, 13.33%
Weight Increased: 1 person, 6.67%
Weight Fluctuation: 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

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