Entresto and Dapsone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Entresto (sacubitril; valsartan) and Dapsone (dapsone). Common drug interactions include diastolic dysfunction among females and blister among males.

The phase IV clinical study analyzes what interactions people have when they take Entresto and Dapsone. It is created by eHealthMe based on reports of 6 people who take the same drugs from the FDA, and is updated regularly.

What is Entresto?

Entresto has active ingredients of sacubitril; valsartan. eHealthMe is studying from 126,612 Entresto users. Check the latest studies of Entresto.

What is Dapsone?

Dapsone has active ingredients of dapsone. It is often used in dermatitis herpetiformis. eHealthMe is studying from 11,731 Dapsone users. Check the latest studies of Dapsone.

On Oct, 27, 2025

6 people who take Entresto and Dapsone together, and have interactions are studied.

What are the common drug interactions of Entresto and Dapsone, by gender? *:

female:

Diastolic dysfunction
Essential hypertension (primary hypertension)
Hyperkalaemia (damage to or disease of the kidney)
Obesity (having too much body fat)
Peripheral vascular disorder
Fatigue (feeling of tiredness)
Adverse reaction
Injection site erythema (redness at injection site)
Injection site pain
Injection site pruritus (severe itching at injection site)

male:

Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Diarrhoea
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Oral mucosal blistering (mouth ulcer)

What are the common drug interactions of Entresto and Dapsone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Adverse reaction
Diarrhoea
Graft versus host disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body)
Injection site erythema (redness at injection site)
Injection site pain
Injection site pruritus (severe itching at injection site)
Injection site reaction
Injection site urticaria (rash of round, red welts on the skin at injection site)

60+:

Acute left ventricular failure (heart attack)
Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
Fatigue (feeling of tiredness)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Dermatitis atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder)
Oral mucosal blistering (mouth ulcer)
Cardiac failure acute
Cardiac failure congestive
Diabetic foot infection
Diastolic dysfunction

* Approximation only. Some reports may have incomplete information.

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