Entresto and Daptomycin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Entresto (sacubitril; valsartan) and Daptomycin (daptomycin). Common drug interactions include pain among females and anaemia among males.

The phase IV clinical study analyzes what interactions people have when they take Entresto and Daptomycin. It is created by eHealthMe based on reports of 20 people who take the same drugs from the FDA, and is updated regularly.

What is Entresto?

Entresto has active ingredients of sacubitril; valsartan. eHealthMe is studying from 126,628 Entresto users. Check the latest studies of Entresto.

What is Daptomycin?

Daptomycin has active ingredients of daptomycin. eHealthMe is studying from 7,879 Daptomycin users. Check the latest studies of Daptomycin.

On Jul, 18, 2026

20 people who take Entresto and Daptomycin together, and have interactions are studied.

Entresto and Daptomycin drug interactions.

What are the common drug interactions of Entresto and Daptomycin, by gender? *:

female:

Pain
Arteriosclerosis (thickening and hardening of arteries)
Bacteraemia (presence of bacteria in the blood)
Death
Dehydration (dryness resulting from the removal of water)
Dizziness postural
Dyspnoea exertional (breathlessness or shortness of breath)
Endocarditis (inflammation in heart muscle)
Fatigue (feeling of tiredness)
Hepatomegaly (abnormal enlargement of the liver)

male:

Anaemia (lack of blood)
Anticoagulation drug level above therapeutic
Epistaxis (bleed from the nose)
Lung disorder (lung disease)
Hepatitis (inflammation of the liver)
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Encephalopathy (functioning of the brain is affected by some agent or condition)
Toxic skin eruption (skin breakdown due to toxic substance)

What are the common drug interactions of Entresto and Daptomycin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Administration site pain
Blood creatine phosphokinase increased
Pain
Anaphylactic shock (severe and rapid and sometimes fatal hypersensitivity reaction to a substance)
Encephalopathy (functioning of the brain is affected by some agent or condition)

50-59:

n/a

60+:

Anaemia (lack of blood)
Anticoagulation drug level above therapeutic
Endocarditis (inflammation in heart muscle)
Fatigue (feeling of tiredness)
Hepatitis (inflammation of the liver)
Hepatomegaly (abnormal enlargement of the liver)
Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Oedema peripheral (superficial swelling)
Sepsis (a severe blood infection that can lead to organ failure and death)

What are the existing conditions these people have? *

Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 35.00%
Staphylococcal Infection (an infection with staphylococcus bacteria): 6 people, 30.00%
Endocarditis (inflammation in heart muscle): 6 people, 30.00%
Left Ventricular Failure (left ventricle fails to contract forcefully): 3 people, 15.00%
Pain: 2 people, 10.00%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 10.00%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 1 person, 5.00%
Post Procedural Infection: 1 person, 5.00%
Enterococcal Infection: 1 person, 5.00%
Cardiac Failure: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

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