Entresto and Epipen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Entresto (sacubitril; valsartan) and Epipen (epinephrine). Common drug interactions include dysphagia among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Entresto and Epipen. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Entresto?

Entresto has active ingredients of sacubitril; valsartan. eHealthMe is studying from 126,628 Entresto users. Check the latest studies of Entresto.

What is Epipen?

Epipen has active ingredients of epinephrine. It is often used in anaphylaxis. eHealthMe is studying from 23,760 Epipen users. Check the latest studies of Epipen.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 22, 2026

24 people who take Entresto and Epipen together, and have interactions are studied.

What are the common drug interactions of Entresto and Epipen, by gender? *:

female:

Dysphagia (a condition in which swallowing is difficult or painful)
Rhinorrhoea (watery mucus discharge from the nose)
Abdominal discomfort
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Blood glucose increased
Cough
Hypoacusis (loss of hearing)
Joint injury
Memory impairment
Overdose

male:

Dyspnoea (difficult or laboured respiration)
Weight decreased
Dizziness postural
Drooling (drop saliva uncontrollably from the mouth)
Dyspnoea exertional (breathlessness or shortness of breath)
Eye pruritus (eye itching)
Eye swelling
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Hypotension (abnormally low blood pressure)
Laryngeal oedema (swelling of larynx)

What are the common drug interactions of Entresto and Epipen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Muscle spasms (muscle contraction)

40-49:

Arthralgia (joint pain)
Arthropathy
Asthma
Biliary dilatation
Cardiac failure chronic
Depression
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)
Hyperhidrosis (abnormally increased sweating)
Hyperlipidaemia (presence of excess lipids in the blood)
Hypersensitivity

50-59:

Chronic kidney disease
Dysphonia (speech disorder attributable to a disorder of phonation)
Dyspnoea (difficult or laboured respiration)
Eye pruritus (eye itching)
Eye swelling
Haemoptysis (blood-stained sputum from the bronchi, larynx, trachea, or lungs)
Laryngeal oedema (swelling of larynx)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Renal failure (kidney dysfunction)
Throat irritation

60+:

Drooling (drop saliva uncontrollably from the mouth)
Nausea (feeling of having an urge to vomit)
Oxygen saturation decreased
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect)
Renal impairment (severely reduced kidney function)
Weight decreased
Angioedema (rapid swelling of the dermis)
C1 esterase inhibitor decreased
Chronic kidney disease
Dysarthria (speech disorder)

What are the existing conditions these people have? *

High Blood Pressure: 6 people, 25.00%
Insomnia (sleeplessness): 5 people, 20.83%
Wheezing (a high-pitched whistling sound made while you breath): 4 people, 16.67%
High Blood Cholesterol: 3 people, 12.50%
Pain: 3 people, 12.50%
Immunodeficiency Common Variable: 3 people, 12.50%
Hypersensitivity: 3 people, 12.50%
Dyspnea (difficult or laboured breathing): 3 people, 12.50%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 3 people, 12.50%
Gout (uric acid crystals building up in the body): 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

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