Entresto and Fentanyl drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Entresto (sacubitril; valsartan) and Fentanyl (fentanyl citrate). Common drug interactions include agranulocytosis among females and disturbance in attention among males.

The phase IV clinical study analyzes what interactions people have when they take Entresto and Fentanyl. It is created by eHealthMe based on reports of 12 people who take the same drugs from the FDA, and is updated regularly.

What is Entresto?

Entresto has active ingredients of sacubitril; valsartan. eHealthMe is studying from 126,628 Entresto users. Check the latest studies of Entresto.

What is Fentanyl?

Fentanyl has active ingredients of fentanyl citrate. It is often used in pain. eHealthMe is studying from 73,301 Fentanyl users. Check the latest studies of Fentanyl.

On Jul, 20, 2026

12 people who take Entresto and Fentanyl together, and have interactions are studied.

Entresto and Fentanyl drug interactions.

What are the common drug interactions of Entresto and Fentanyl, by gender? *:

female:

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection)
Death
Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Neuropathy peripheral (surface nerve damage)
Weight decreased

male:

Disturbance in attention
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Cardiomyopathy (weakening of the heart muscle)
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Femur fracture
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Heart rate increased
Hip fracture
Hyperammonaemia

What are the common drug interactions of Entresto and Fentanyl, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Cardio-respiratory arrest (sudden dysfunction of heart and lungs)
Diarrhoea
Gastrointestinal haemorrhage (bleeding gastrointestinal tract)
Heart rate increased
Hyperammonaemia
Hypoglycaemia (deficiency of glucose in the bloodstream)
Hypotension (abnormally low blood pressure)
Hypovolaemic shock (shock caused by severe blood or fluid loss)
Jaundice (a yellowish pigmentation of the skin, the conjunctival membranes)
Lethargy (tiredness)

60+:

Dyspnoea (difficult or laboured respiration)
Fatigue (feeling of tiredness)
Insomnia (sleeplessness)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)
Neuropathy peripheral (surface nerve damage)
Weight decreased

What are the existing conditions these people have? *

Cardiac Failure Chronic: 2 people, 16.67%
Sleep Disorder: 1 person, 8.33%
High Blood Cholesterol: 1 person, 8.33%
Fibromyalgia (a long-term condition which causes pain all over the body): 1 person, 8.33%
Cardiac Failure: 1 person, 8.33%
Back Pain: 1 person, 8.33%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

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