Entresto and Invokana drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Entresto (sacubitril; valsartan) and Invokana (canagliflozin). Common drug interactions include diarrhoea among females and dizziness among males.

The phase IV clinical study analyzes what interactions people have when they take Entresto and Invokana. It is created by eHealthMe based on reports of 55 people who take the same drugs from the FDA, and is updated regularly.

What is Entresto?

Entresto has active ingredients of sacubitril; valsartan. eHealthMe is studying from 126,628 Entresto users. Check the latest studies of Entresto.

What is Invokana?

Invokana has active ingredients of canagliflozin. It is often used in diabetes. eHealthMe is studying from 29,937 Invokana users. Check the latest studies of Invokana.

On Jul, 04, 2026

55 people who take Entresto and Invokana together, and have interactions are studied.

Entresto and Invokana drug interactions.

What are the common drug interactions of Entresto and Invokana, by gender? *:

female:

Diarrhoea
Dizziness postural
Drug ineffective
Dyspepsia (indigestion)
Fluid retention (an abnormal accumulation of fluid in the blood)
Headache (pain in head)
Hunger
Hypotension (abnormally low blood pressure)
Insomnia (sleeplessness)
Lung neoplasm malignant (cancer tumour of lung)

male:

Dizziness
Dyspnoea (difficult or laboured respiration)
Weight increased
Back pain
Ventricular arrhythmia (problem with the rate or rhythm of the heartbeat)
Chest discomfort
Hyperkalaemia (damage to or disease of the kidney)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Nausea (feeling of having an urge to vomit)
Renal failure (kidney dysfunction)

What are the common drug interactions of Entresto and Invokana, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Genital abscess (build up of pus in genital)
Groin abscess (pus in groin)
Pelvic abscess
Perineal abscess
Scrotal abscess (pus in scrotum)
Scrotal gangrene (death of scrotum cells)
Sepsis (a severe blood infection that can lead to organ failure and death)
Septic shock (shock due to blood infection)
Subcutaneous abscess
Urinary tract infection

40-49:

Angioedema (rapid swelling of the dermis)
Lip swelling
Swelling face
Swollen tongue (swelling of tongue)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Urticaria (rash of round, red welts on the skin that itch intensely)

50-59:

Aphasia (damage to the parts of the brain that control language)
Back pain
Depression
Gait disturbance
Hypoaesthesia (reduced sense of touch or sensation)
Memory impairment
Tremor (trembling or shaking movements in one or more parts of your body)
Visual impairment
Cardiovascular disorder (heart diseases)
Death

60+:

Dizziness
Dyspnoea (difficult or laboured respiration)
Weight increased
Back pain
Ventricular arrhythmia (problem with the rate or rhythm of the heartbeat)
Hyperkalaemia (damage to or disease of the kidney)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Herpes zoster
Pneumonia
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

Cardiac Failure: 22 people, 40.00%
Hyperkalemia (damage to or disease of the kidney): 12 people, 21.82%
Type 2 Diabetes: 6 people, 10.91%
High Blood Pressure: 5 people, 9.09%
Chest Pain: 5 people, 9.09%
Arrhythmias (irregular heartbeat): 4 people, 7.27%
Parkinson's Disease: 3 people, 5.45%
High Blood Cholesterol: 3 people, 5.45%
Depression: 3 people, 5.45%
Cardiac Disorder: 3 people, 5.45%

* Approximation only. Some reports may have incomplete information.

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