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Entresto and Naltrexone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Entresto (sacubitril; valsartan) and Naltrexone (naltrexone). Common drug interactions include drug screen positive among females and cardiac disorder among males.

The phase IV clinical study analyzes what interactions people have when they take Entresto and Naltrexone. It is created by eHealthMe based on reports of 6 people who take the same drugs from the FDA, and is updated regularly.

What is Entresto?

Entresto has active ingredients of sacubitril; valsartan. eHealthMe is studying from 126,618 Entresto users. Check the latest studies of Entresto.

What is Naltrexone?

Naltrexone has active ingredients of naltrexone. eHealthMe is studying from 4,829 Naltrexone users. Check the latest studies of Naltrexone.

On Feb, 11, 2026

6 people who take Entresto and Naltrexone together, and have interactions are studied.

Entresto and Naltrexone drug interactions.

What are the common drug interactions of Entresto and Naltrexone, by gender? *:

female:

  1. Drug screen positive
  2. Fall
  3. Haemorrhage (bleeding)
  4. Head injury
  5. Syncope (loss of consciousness with an inability to maintain postural tone)

male:

  1. Cardiac disorder

What are the common drug interactions of Entresto and Naltrexone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

  1. Drug screen positive
  2. Fall
  3. Haemorrhage (bleeding)
  4. Head injury
  5. Syncope (loss of consciousness with an inability to maintain postural tone)

40-49:

n/a

50-59:

n/a

60+:

  1. Cardiac disorder

* Approximation only. Some reports may have incomplete information.

Do you take Entresto and Naltrexone?

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Entresto and Naltrexone:

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Browse all side effects of Entresto:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Naltrexone:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Entresto and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Naltrexone and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on sacubitril; valsartan and naltrexone (the active ingredients of Entresto and Naltrexone, respectively), and Entresto and Naltrexone (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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