Entresto and Vicodin drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Entresto (sacubitril; valsartan) and Vicodin (acetaminophen; hydrocodone bitartrate). Common drug interactions include dehydration among females and dyspnoea among males.

The phase IV clinical study analyzes what interactions people have when they take Entresto and Vicodin. It is created by eHealthMe based on reports of 25 people who take the same drugs from the FDA, and is updated regularly.

What is Entresto?

Entresto has active ingredients of sacubitril; valsartan. eHealthMe is studying from 126,628 Entresto users. Check the latest studies of Entresto.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

On Jul, 11, 2026

25 people who take Entresto and Vicodin together, and have interactions are studied.

What are the common drug interactions of Entresto and Vicodin, by gender? *:

female:

Dehydration (dryness resulting from the removal of water)
Dizziness
Insomnia (sleeplessness)
Cardiac disorder
Fall
Fatigue (feeling of tiredness)
Joint dislocation (a joint position is changed from normal position)
Arthralgia (joint pain)
Blood pressure decreased
Blood pressure diastolic increased

male:

Dyspnoea (difficult or laboured respiration)
Malaise (a feeling of general discomfort or uneasiness)
Urinary retention (the inability to completely or partially empty the bladder)
Cardiac failure acute
Decreased appetite
Decubitus ulcer (a chronic ulcer of the skin caused by prolonged pressure on it)
Dehydration (dryness resulting from the removal of water)
Infection
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Oedema peripheral (superficial swelling)

What are the common drug interactions of Entresto and Vicodin, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Blood pressure decreased
Dehydration (dryness resulting from the removal of water)
Headache (pain in head)
Therapeutic response unexpected

60+:

Fatigue (feeling of tiredness)
Decreased appetite
Middle insomnia (difficulty returning to sleep after awakening either in the middle of the night)
Mobility decreased (ability to move is reduced)
Pain in extremity
Productive cough
Retching (strong involuntary effort to vomit)
Arthralgia (joint pain)
Blood pressure diastolic increased
Blood pressure increased

What are the existing conditions these people have? *

Cardiac Failure: 4 people, 16.00%
Thyroid Cancer: 3 people, 12.00%
High Blood Cholesterol: 3 people, 12.00%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 2 people, 8.00%
Pain In Extremity: 2 people, 8.00%
Multiple Myeloma (cancer of the plasma cells): 2 people, 8.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 8.00%
Fluid Retention (an abnormal accumulation of fluid in the blood): 2 people, 8.00%
Diabetes: 2 people, 8.00%
Cardiac Disorder: 2 people, 8.00%

* Approximation only. Some reports may have incomplete information.

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