Enulose and Diphen drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Enulose (lactulose) and Diphen (diphenhydramine hydrochloride). Common drug interactions include laryngeal discomfort among females and ileus among males.

The phase IV clinical study analyzes what interactions people have when they take Enulose and Diphen. It is created by eHealthMe based on reports of 44 people who take the same drugs from the FDA, and is updated regularly.

What is Enulose?

Enulose has active ingredients of lactulose. It is often used in constipation. eHealthMe is studying from 711 Enulose users. Check the latest studies of Enulose.

What is Diphen?

Diphen has active ingredients of diphenhydramine hydrochloride. It is often used in insomnia. eHealthMe is studying from 115,432 Diphen users. Check the latest studies of Diphen.

On Jul, 09, 2026

44 people who take Enulose and Diphen together, and have interactions are studied.

What are the common drug interactions of Enulose and Diphen, by gender? *:

female:

Laryngeal discomfort
Macular degeneration (painless eye condition that leads to the gradual loss of central vision)
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Renal failure (kidney dysfunction)
Surgery
Unresponsive to stimuli
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Headache (pain in head)
Vomiting

male:

Ileus (a painful obstruction of the ileum or other part of the intestine)
Pneumonia
Rash
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sinusitis (inflammation of sinus)
Tachycardia (a heart rate that exceeds the range of 100 beats/min)
Tachypnoea (a condition of rapid breathing over 20 per minute)
Cytomegalovirus infection
Headache (pain in head)
Peritonitis (inflammation of the peritoneum, the thin tissue that lines the inner wall of the abdomen and covers most of the abdominal organs)

What are the common drug interactions of Enulose and Diphen, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

Agitation (state of anxiety or nervous excitement)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Drug intolerance (drug sensitivity)
Fall
Infusion related reaction
Lymphadenopathy (disease or enlargement of lymph nodes)
Pyrexia (fever)
Rash
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Sinusitis (inflammation of sinus)

30-39:

n/a

40-49:

Ileus (a painful obstruction of the ileum or other part of the intestine)
Pneumonia
Septic shock (shock due to blood infection)
Death
Adrenal adenoma (benign tumour of the glandular type (adenoma) in the adrenal gland)
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)
Anaemia (lack of blood)
Anaemia of malignant disease
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety

50-59:

Arthralgia (joint pain)
Autoimmune disorder (a condition in which the immune system attacks the body's normal substances and tissue)
Back pain
Biliary colic
Blindness
Blood creatinine increased
Bone disorder
Bone lesion (bone with abnormalities. bone lesions can result from growth formations, infections, or injuries)
Bone pain
Bronchitis (inflammation of the mucous membrane in the bronchial tubes)

60+:

Pain
Anxiety
Abdominal pain
Anaemia (lack of blood)
Catheter site swelling
Fatigue (feeling of tiredness)
Fungal skin infection
Lethargy (tiredness)
Small intestinal obstruction (blockage in small intestine)
Upper respiratory tract infection

What are the existing conditions these people have? *

High Blood Pressure: 11 people, 25.00%
Immunodeficiency Common Variable: 10 people, 22.73%
Pain: 9 people, 20.45%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 9 people, 20.45%
Depression: 8 people, 18.18%
High Blood Cholesterol: 8 people, 18.18%
Nausea (feeling of having an urge to vomit): 7 people, 15.91%
Stress And Anxiety: 6 people, 13.64%
Inflammation: 5 people, 11.36%
Back Pain: 5 people, 11.36%

* Approximation only. Some reports may have incomplete information.

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