Epclusa and Dapsone drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epclusa (sofosbuvir; velpatasvir) and Dapsone (dapsone). Common drug interactions include transplant rejection among females and renal impairment among males.

The phase IV clinical study analyzes what interactions people have when they take Epclusa and Dapsone. It is created by eHealthMe based on reports of 6 people who take the same drugs from the FDA, and is updated regularly.

What is Epclusa?

Epclusa has active ingredients of sofosbuvir; velpatasvir. eHealthMe is studying from 12,120 Epclusa users. Check the latest studies of Epclusa.

What is Dapsone?

Dapsone has active ingredients of dapsone. It is often used in dermatitis herpetiformis. eHealthMe is studying from 11,732 Dapsone users. Check the latest studies of Dapsone.

On Jun, 27, 2026

6 people who take Epclusa and Dapsone together, and have interactions are studied.

What are the common drug interactions of Epclusa and Dapsone, by gender? *:

female:

Transplant rejection (a transplant material is not worked)
Aphasia (damage to the parts of the brain that control language)
Balance disorder
Blood fibrinogen decreased
Cardiorenal syndrome (kidney failure and heart failure)
Cryoglobulinaemia (blood contains large amounts of cryoglobulins - proteins)
Diastolic dysfunction
Dysarthria (speech disorder)
Fatigue (feeling of tiredness)
Glomerulonephritis (a group of conditions that affect parts of the kidneys called glomeruli)

male:

Renal impairment (severely reduced kidney function)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Hyperkalaemia (damage to or disease of the kidney)
Rib fracture
Anxiety
Blood creatinine increased
Bone density decreased
Emotional distress
Joint injury

What are the common drug interactions of Epclusa and Dapsone, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Renal impairment (severely reduced kidney function)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood creatinine increased
Bone density decreased
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Emotional distress
Hyperkalaemia (damage to or disease of the kidney)
Joint injury
Osteopenia (a condition where bone mineral density is lower than normal)

60+:

Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood creatinine increased
Bone density decreased
Emotional distress
Joint injury
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain
Renal impairment (severely reduced kidney function)

* Approximation only. Some reports may have incomplete information.

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