Epclusa and Hydroxyzine hydrochloride drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epclusa (sofosbuvir; velpatasvir) and Hydroxyzine hydrochloride (hydroxyzine hydrochloride). Common drug interactions include headache among females and diarrhoea among males.

The phase IV clinical study analyzes what interactions people have when they take Epclusa and Hydroxyzine hydrochloride. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Epclusa?

Epclusa has active ingredients of sofosbuvir; velpatasvir. eHealthMe is studying from 12,120 Epclusa users. Check the latest studies of Epclusa.

What is Hydroxyzine hydrochloride?

Hydroxyzine hydrochloride has active ingredients of hydroxyzine hydrochloride. It is often used in stress and anxiety. eHealthMe is studying from 10,486 Hydroxyzine hydrochloride users. Check the latest studies of Hydroxyzine hydrochloride.

On Jul, 13, 2026

26 people who take Epclusa and Hydroxyzine hydrochloride together, and have interactions are studied.

Epclusa and Hydroxyzine hydrochloride drug interactions.

What are the common drug interactions of Epclusa and Hydroxyzine Hydrochloride, by gender? *:

female:

Headache (pain in head)
Nausea (feeling of having an urge to vomit)
Abdominal discomfort
Drug ineffective
Fatigue (feeling of tiredness)
Abdominal pain
Arthralgia (joint pain)
Decreased appetite
Diarrhoea
Genotype drug resistance test positive

male:

Diarrhoea
Abdominal discomfort
Drug ineffective
Dyspnoea (difficult or laboured respiration)
Faeces discoloured
Gastric disorder (disease of stomach)
Haemoglobin decreased
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Oesophageal varices haemorrhage (bleeding from extremely dilated sub-mucosal veins in the lower third of the oesophagus)
Portal hypertension (increase in the blood pressure within a system of veins called the portal venous system)

What are the common drug interactions of Epclusa and Hydroxyzine Hydrochloride, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

Renal impairment (severely reduced kidney function)
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Blood creatinine increased
Bone density decreased
Emotional distress
Hyperkalaemia (damage to or disease of the kidney)
Joint injury
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)
Pain

60+:

Abdominal discomfort
Diarrhoea
Dyspnoea (difficult or laboured respiration)
Faeces discoloured
Gastric disorder (disease of stomach)
Haemoglobin decreased
Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone)
Nausea (feeling of having an urge to vomit)
Oesophageal varices haemorrhage (bleeding from extremely dilated sub-mucosal veins in the lower third of the oesophagus)
Pain

What are the existing conditions these people have? *

Hepatitis C: 3 people, 11.54%

* Approximation only. Some reports may have incomplete information.

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