Epclusa and Ketoconazole drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epclusa (sofosbuvir; velpatasvir) and Ketoconazole (ketoconazole). Common drug interactions include blood pressure inadequately controlled among females and fatigue among males.

The phase IV clinical study analyzes what interactions people have when they take Epclusa and Ketoconazole. It is created by eHealthMe based on reports of 17 people who take the same drugs from the FDA, and is updated regularly.

What is Epclusa?

Epclusa has active ingredients of sofosbuvir; velpatasvir. eHealthMe is studying from 12,120 Epclusa users. Check the latest studies of Epclusa.

What is Ketoconazole?

Ketoconazole has active ingredients of ketoconazole. It is often used in fungal infection. eHealthMe is studying from 16,014 Ketoconazole users. Check the latest studies of Ketoconazole.

On Jul, 12, 2026

17 people who take Epclusa and Ketoconazole together, and have interactions are studied.

Epclusa and Ketoconazole drug interactions.

What are the common drug interactions of Epclusa and Ketoconazole, by gender? *:

female:

Blood pressure inadequately controlled
Catheter site pain
Hyperkalaemia (damage to or disease of the kidney)
Sepsis (a severe blood infection that can lead to organ failure and death)
Anxiety
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Abdominal pain
Blood iron increased
Catheter site erythema (redness of skin at catheter site)
Depression

male:

Fatigue (feeling of tiredness)
Vomiting
Hallucination (an experience involving the perception of something not present)
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Muscle spasms (muscle contraction)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteopenia (a condition where bone mineral density is lower than normal)
Pain
Renal failure (kidney dysfunction)

What are the common drug interactions of Epclusa and Ketoconazole, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

Abdominal pain
Blood pressure inadequately controlled
Catheter site pain
Erythema (redness of the skin)
Hyperkalaemia (damage to or disease of the kidney)
Renal impairment (severely reduced kidney function)
Sepsis (a severe blood infection that can lead to organ failure and death)
Skin disorder (skin disease)
Skin infection
Soft tissue infection

50-59:

Bone density decreased
Chronic kidney disease
Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving)
Emotional distress
Gastrointestinal disorder (functional problems of gastrointestinal tract)
Hallucination (an experience involving the perception of something not present)
Osteoarthritis (a joint disease caused by cartilage loss in a joint)
Osteopenia (a condition where bone mineral density is lower than normal)
Pain
Renal failure (kidney dysfunction)

60+:

Fatigue (feeling of tiredness)
Chest pain
Headache (pain in head)
Malaise (a feeling of general discomfort or uneasiness)
Muscle spasms (muscle contraction)
Vomiting
Abdominal discomfort
Amnesia (deficit in memory caused by brain damage, disease, or psychological trauma)

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 23.53%
Hiv Infection: 2 people, 11.76%
Hepatitis C: 2 people, 11.76%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 5.88%

* Approximation only. Some reports may have incomplete information.

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