Epclusa and Methocarbamol drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epclusa (sofosbuvir; velpatasvir) and Methocarbamol (methocarbamol). Common drug interactions include anxiety among females and dyspepsia among males.

The phase IV clinical study analyzes what interactions people have when they take Epclusa and Methocarbamol. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Epclusa?

Epclusa has active ingredients of sofosbuvir; velpatasvir. eHealthMe is studying from 12,120 Epclusa users. Check the latest studies of Epclusa.

What is Methocarbamol?

Methocarbamol has active ingredients of methocarbamol. It is often used in muscle spasms. eHealthMe is studying from 17,766 Methocarbamol users. Check the latest studies of Methocarbamol.

On Aug, 09, 2026

26 people who take Epclusa and Methocarbamol together, and have interactions are studied.

Epclusa and Methocarbamol drug interactions.

What are the common drug interactions of Epclusa and Methocarbamol, by gender? *:

female:

Anxiety
Vomiting
Attention deficit hyperactivity disorder (a chronic condition including attention difficulty, hyperactivity, and impulsiveness)
Depression
Headache (pain in head)
Muscle fatigue (a condition in which muscles cannot exert their normal force)
Nausea (feeling of having an urge to vomit)
Abdominal discomfort
Dysmenorrhoea (painful menstruation)
Fatigue (feeling of tiredness)

male:

Dyspepsia (indigestion)
Headache (pain in head)
Fatigue (feeling of tiredness)
Feeling jittery
Flatulence (flatus expelled through the anus)
Insomnia (sleeplessness)
Liver disorder (liver diseases)
Malaise (a feeling of general discomfort or uneasiness)
Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

What are the common drug interactions of Epclusa and Methocarbamol, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Malaise (a feeling of general discomfort or uneasiness)

40-49:

Abdominal discomfort
Dysmenorrhoea (painful menstruation)
Fatigue (feeling of tiredness)
Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
Overdose
Vomiting

50-59:

Anxiety
Chronic obstructive pulmonary disease (a progressive disease that makes it hard to breathe)
Diarrhoea
Dyspepsia (indigestion)
Mood altered (changes in mood)
Myocardial infarction (destruction of heart tissue resulting from obstruction of the blood supply to the heart muscle)

60+:

Decreased appetite
Energy increased
Tremor (trembling or shaking movements in one or more parts of your body)
Weight increased
Euphoric mood (excessively happy but may become angry or irritable)
Feeling jittery
Flatulence (flatus expelled through the anus)
Headache (pain in head)
Insomnia (sleeplessness)
Irritability

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 15.38%

* Approximation only. Some reports may have incomplete information.

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