Epclusa and Promethazine drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epclusa (sofosbuvir; velpatasvir) and Promethazine (promethazine hydrochloride). Common drug interactions include headache among females and death among males.

The phase IV clinical study analyzes what interactions people have when they take Epclusa and Promethazine. It is created by eHealthMe based on reports of 24 people who take the same drugs from the FDA, and is updated regularly.

What is Epclusa?

Epclusa has active ingredients of sofosbuvir; velpatasvir. eHealthMe is studying from 12,120 Epclusa users. Check the latest studies of Epclusa.

What is Promethazine?

Promethazine has active ingredients of promethazine hydrochloride. It is often used in nausea. eHealthMe is studying from 32,300 Promethazine users. Check the latest studies of Promethazine.

On Jul, 28, 2026

24 people who take Epclusa and Promethazine together, and have interactions are studied.

Epclusa and Promethazine drug interactions.

What are the common drug interactions of Epclusa and Promethazine, by gender? *:

female:

Headache (pain in head)
Intentional self-injury
Alcoholism (problems with alcohol)
Alopecia (absence of hair from areas of the body)
Apathy
Decreased interest
Diarrhoea
Dry skin
Faeces discoloured
Gastrooesophageal reflux disease (stomach contents (food or liquid) leak backwards from the stomach into the oesophagus)

male:

Death
Renal impairment (severely reduced kidney function)
Osteoporosis (bones weak and more likely to break)
Pain
Pneumonia
Hepatitis c
Abdominal tenderness
Aggression
Agitation (state of anxiety or nervous excitement)
Ascites (accumulation of fluid in the abdominal cavity)

What are the common drug interactions of Epclusa and Promethazine, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

Alopecia (absence of hair from areas of the body)
Apathy
Decreased interest
Dry skin
Headache (pain in head)
Mental disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability)
Pain in extremity
Pruritus (severe itching of the skin)
Psychotic disorder
Rash

40-49:

Death
Hepatitis c
Aggression
Agitation (state of anxiety or nervous excitement)
Alcoholism (problems with alcohol)

50-59:

Renal impairment (severely reduced kidney function)
Abdominal pain
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Anxiety
Blood creatinine increased
Bone density decreased
Emotional distress
Hyperkalaemia (damage to or disease of the kidney)
Influenza like illness
Joint injury

60+:

Pneumonia
Anhedonia (inability to experience pleasure from activities usually found enjoyable)
Renal impairment (severely reduced kidney function)
Anxiety
Blood creatinine increased
Bone density decreased
Emotional distress
Joint injury
Osteopenia (a condition where bone mineral density is lower than normal)
Osteoporosis (bones weak and more likely to break)

What are the existing conditions these people have? *

Hepatitis C: 11 people, 45.83%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 8.33%
Muscle Spasms (muscle contraction): 2 people, 8.33%
Hiv Infection: 2 people, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Epclusa and Promethazine?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously