Epidiolex and Botox drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epidiolex (cannabidiol) and Botox (botulinum toxin type a). Common drug interactions include hypothermia among females and seizure among males.

The phase IV clinical study analyzes what interactions people have when they take Epidiolex and Botox. It is created by eHealthMe based on reports of 37 people who take the same drugs from the FDA, and is updated regularly.

What is Epidiolex?

Epidiolex has active ingredients of cannabidiol. eHealthMe is studying from 18,763 Epidiolex users. Check the latest studies of Epidiolex.

What is Botox?

Botox has active ingredients of botulinum toxin type a. It is often used in migraine. eHealthMe is studying from 70,513 Botox users. Check the latest studies of Botox.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 29, 2026

37 people who take Epidiolex and Botox together, and have interactions are studied.

What are the common drug interactions of Epidiolex and Botox, by gender? *:

female:

Hypothermia (body temperature drops below the required temperature for normal metabolism and body functions)
Pneumonia
Skin exfoliation (removal of the oldest dead skin cells)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Cough
Death
Flatulence (flatus expelled through the anus)
Petechiae (a small red or purple spot caused by bleeding into the skin)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)
Pyrexia (fever)

male:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Hospitalisation
Movement disorder (neurological syndromes where they may be excess of movement or a paucity of movement that is not connected to weakness)
Drug ineffective
Death
Muscle spasms (muscle contraction)
Small intestinal obstruction (blockage in small intestine)

What are the common drug interactions of Epidiolex and Botox, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

Cough
Flatulence (flatus expelled through the anus)
Muscle spasms (muscle contraction)
Petechiae (a small red or purple spot caused by bleeding into the skin)
Pyrexia (fever)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Small intestinal obstruction (blockage in small intestine)
Vomiting

10-19:

Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Cerebrovascular accident (sudden death of some brain cells due to lack of oxygen when the blood flow to the brain is impaired by blockage or rupture)
Death

20-29:

n/a

30-39:

Lethargy (tiredness)
Pneumonia aspiration (bronchopneumonia that develops due to the entrance of foreign materials into the bronchial tree)

40-49:

n/a

50-59:

n/a

60+:

n/a

What are the existing conditions these people have? *

Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 8 people, 21.62%
Epilepsy (common and diverse set of chronic neurological disorders characterized by seizures): 7 people, 18.92%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 6 people, 16.22%
Cerebral Palsy: 4 people, 10.81%
Wheezing (a high-pitched whistling sound made while you breath): 2 people, 5.41%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 5.41%
Psoriasis (immune-mediated disease that affects the skin): 2 people, 5.41%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 2 people, 5.41%
Movement - Uncontrolled Or Slow: 2 people, 5.41%

* Approximation only. Some reports may have incomplete information.

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