Epiduo and Zipsor drug interactions - a phase IV clinical study of FDA data
Summary:
Drug interactions are reported among people who take Epiduo (adapalene; benzoyl peroxide) and Zipsor (diclofenac potassium). Common drug interactions include post procedural complication among females.
The phase IV clinical study analyzes what interactions people have when they take Epiduo and Zipsor. It is created by eHealthMe based on reports of 18 people who take the same drugs from the FDA, and is updated regularly.
What is Epiduo?
Epiduo has active ingredients of adapalene; benzoyl peroxide. It is often used in acne. eHealthMe is studying from 1,581 Epiduo users. Check the latest studies of Epiduo.
What is Zipsor?
Zipsor has active ingredients of diclofenac potassium. It is often used in arthritis. eHealthMe is studying from 480 Zipsor users. Check the latest studies of Zipsor.
18 people who take Epiduo and Zipsor together, and have interactions are studied.

What are the common drug interactions of Epiduo and Zipsor, by gender? *:
female:
- Post procedural complication
- Suicidal ideation
- Mycoplasma infection (bacterial infection)
- Nausea (feeling of having an urge to vomit)
- Retching (strong involuntary effort to vomit)
- Skin irritation
- Urethral polyp
- Vitamin d decreased
- Blood oestrogen decreased
- Blood testosterone decreased
male:
n/a
What are the common drug interactions of Epiduo and Zipsor, by age (0-1 to 60+)? *:
0-1:
n/a
2-9:
n/a
10-19:
n/a
20-29:
- Post procedural complication
- Fibromyalgia (a long-term condition which causes pain all over the body)
- Urethral polyp
- Gastroenteritis viral (inflammation of stomach and intestine caused by virus infection)
- Hypercoagulation (increased tendency for clotting of the blood)
- Neuralgia (pain in one or more nerves)
- Suicidal ideation
- Colitis (inflammation of colon)
- Drug hypersensitivity
- Retching (strong involuntary effort to vomit)
30-39:
n/a
40-49:
n/a
50-59:
n/a
60+:
n/a
What are the existing conditions these people have? *
- Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 17 people, 94.44%
- Cataplexy (loss of muscle tone accompanied by full conscious awareness): 17 people, 94.44%
* Approximation only. Some reports may have incomplete information.
Do you take Epiduo and Zipsor?
- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously
Related studies:
Effectiveness of, side effects of, and alternative drugs to the 2 drugs:
Browse all drug interactions of Epiduo and Zipsor:
a b c d e f g h i j k l m n o p q r s t u v w x y zSub-studies by gender and age:
Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+
Browse all side effects of Epiduo:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all side effects of Zipsor:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Epiduo and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zBrowse all interactions between Zipsor and drugs from A to Z:
a b c d e f g h i j k l m n o p q r s t u v w x y zHow the study uses the data?
The study uses data from the FDA. It is based on adapalene; benzoyl peroxide and diclofenac potassium (the active ingredients of Epiduo and Zipsor, respectively), and Epiduo and Zipsor (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.
How to use the study?
DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.
Who is eHealthMe?
With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).
WARNING, DISCLAIMER, USE FOR PUBLICATION
WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.
DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.
If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.
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