Epinephrine and Norepinephrine bitartrate drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epinephrine (epinephrine) and Norepinephrine bitartrate (norepinephrine bitartrate). Common drug interactions include rash among females and drug ineffective among males.

The phase IV clinical study analyzes what interactions people have when they take Epinephrine and Norepinephrine bitartrate. It is created by eHealthMe based on reports of 69 people who take the same drugs from the FDA, and is updated regularly.

What is Epinephrine?

Epinephrine has active ingredients of epinephrine. It is often used in asthma. eHealthMe is studying from 21,290 Epinephrine users. Check the latest studies of Epinephrine.

What is Norepinephrine bitartrate?

Norepinephrine bitartrate has active ingredients of norepinephrine bitartrate. eHealthMe is studying from 2,370 Norepinephrine bitartrate users. Check the latest studies of Norepinephrine bitartrate.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

69 people who take Epinephrine and Norepinephrine bitartrate together, and have interactions are studied.

Epinephrine and Norepinephrine bitartrate drug interactions.

What are the common drug interactions of Epinephrine and Norepinephrine Bitartrate, by gender? *:

female:

Rash
Respiratory depression (respiration has a rate below 12 breaths)
Seizure (abnormal excessive or synchronous neuronal activity in the brain)
Thrombocytopenia (decrease of platelets in blood)
Toxic epidermal necrolysis (a rare, life-threatening skin condition that is usually caused by a reaction to drugs causes wide spread skin destruction)
Drug ineffective
Bradycardia (abnormally slow heart action)
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Device related infection
Drug eruption (adverse drug reaction of the skin)

male:

Drug ineffective
Hypotension (abnormally low blood pressure)
Acute respiratory distress syndrome
Cardiac arrest
Death
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Pneumonia bacterial (pneumonia associated with bacterial infection)
Septic shock (shock due to blood infection)
Acute lung injury
Burkholderia test positive

What are the common drug interactions of Epinephrine and Norepinephrine Bitartrate, by age (0-1 to 60+)? *:

0-1:

Peripheral ischaemia (impaired circulation to an extremity)

2-9:

n/a

10-19:

Electrocardiogram qt prolonged
Hypotension (abnormally low blood pressure)
Leukocytosis (increased white blood cells)
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Coagulopathy (blood's ability to clot is impaired)
Drug ineffective

20-29:

Bradycardia (abnormally slow heart action)

30-39:

Dry gangrene (diminished blood supply due to vascular problems)
Extremity necrosis (death of body tissue of arms and legs)
Live birth
Maternal exposure during pregnancy (use of substance during pregnancy)
Premature baby
Drug ineffective
Anxiety
Dyspnoea (difficult or laboured respiration)
Normal newborn
Premature delivery

40-49:

Hypokalaemia (low potassium)
Cardiac arrest
Metabolic acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body)
Stress cardiomyopathy (stress-induced chronic disease of the heart muscle)
Cardiogenic shock (inadequate circulation of blood)
Hypotension (abnormally low blood pressure)
Ischaemia (insufficient supply of blood to an organ, usually due to a blocked artery)
Overdose
Drug ineffective
Altered state of consciousness (altered state of mind)

50-59:

Drug ineffective
Hypotension (abnormally low blood pressure)
Bradycardia (abnormally slow heart action)
Coma (state of unconsciousness lasting more than six hours)
Respiratory depression (respiration has a rate below 12 breaths)
Ischaemia (insufficient supply of blood to an organ, usually due to a blocked artery)
Acute respiratory distress syndrome
Hypertension (high blood pressure)
Hypertensive emergency
Intestinal ischaemia (decreased supply of oxygenated blood to the intestines)

60+:

Overdose
Cyanosis (lack of oxygen in body leads to blue appearance of skin ,mucous membrane nails)
Bradycardia (abnormally slow heart action)
Drug ineffective
Hypotension (abnormally low blood pressure)
Acute respiratory failure
Coma (state of unconsciousness lasting more than six hours)
Death
Pancreatitis acute (sudden inflammation of pancreas)
Device related infection

What are the existing conditions these people have? *

Hypotension (abnormally low blood pressure): 20 people, 28.99%
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin): 8 people, 11.59%
Urination - Excessive Volume: 4 people, 5.80%
Septic Shock (shock due to blood infection): 4 people, 5.80%
Cardiac Failure: 4 people, 5.80%

* Approximation only. Some reports may have incomplete information.

Do you take Epinephrine and Norepinephrine bitartrate?

- Personalize this study to your gender, age, symptoms and drugs
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously