Epinephrine and Xgeva drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epinephrine (epinephrine) and Xgeva (denosumab). Common drug interactions include fatigue among females and atrial fibrillation among males.

The phase IV clinical study analyzes what interactions people have when they take Epinephrine and Xgeva. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Epinephrine?

Epinephrine has active ingredients of epinephrine. It is often used in asthma. eHealthMe is studying from 21,290 Epinephrine users. Check the latest studies of Epinephrine.

What is Xgeva?

Xgeva has active ingredients of denosumab. It is often used in breast cancer. eHealthMe is studying from 37,717 Xgeva users. Check the latest studies of Xgeva.



On Jul, 28, 2026

26 people who take Epinephrine and Xgeva together, and have interactions are studied.

Epinephrine and Xgeva drug interactions.

What are the common drug interactions of Epinephrine and Xgeva, by gender? *:

female:

  1. Fatigue (feeling of tiredness)
  2. Sinusitis (inflammation of sinus)
  3. Infusion site swelling
  4. Constipation
  5. Diarrhoea
  6. Epistaxis (bleed from the nose)
  7. Food craving
  8. Gastrointestinal disorder (functional problems of gastrointestinal tract)
  9. Headache (pain in head)
  10. Herpes virus infection

male:

  1. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  2. Osteonecrosis of jaw (death of bone of jaw)
  3. Abdominal pain upper
  4. Abscess (pus)
  5. Death
  6. Dementia (madness)
  7. Drug ineffective
  8. General physical health deterioration (weak health status)
  9. Gingivitis (inflammation of gums)
  10. Nasopharyngitis (inflammation of the nasopharynx)

What are the common drug interactions of Epinephrine and Xgeva, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

n/a

20-29:

n/a

30-39:

n/a

40-49:

n/a

50-59:

  1. Abdominal pain upper
  2. Arthralgia (joint pain)
  3. Blood pressure increased
  4. Breast cancer recurrent
  5. Breast cancer stage iv
  6. Bronchitis (inflammation of the mucous membrane in the bronchial tubes)
  7. Contusion (a type of hematoma of tissue in which capillaries)
  8. Cough
  9. Dermatitis contact (skin reaction (dermatitis) resulting from exposure to allergens)
  10. Dizziness

60+:

  1. Atrial fibrillation (fibrillation of the muscles of the atria of the heart)
  2. Osteonecrosis of jaw (death of bone of jaw)
  3. Nasopharyngitis (inflammation of the nasopharynx)
  4. Neutropenia (an abnormally low number of neutrophils)
  5. Pain
  6. Prostate cancer metastatic
  7. Tooth fracture
  8. Weight increased
  9. White blood cell count decreased
  10. Disease progression

What are the existing conditions these people have? *

  1. Immunodeficiency Common Variable: 11 people, 42.31%
  2. Immune System Disorder: 4 people, 15.38%
  3. High Blood Pressure: 3 people, 11.54%
  4. Prostate Cancer Metastatic: 2 people, 7.69%
  5. Metastases To Bone (cancer spreads to bone): 2 people, 7.69%
  6. Lung Neoplasm Malignant (cancer tumour of lung): 2 people, 7.69%
  7. Hypersensitivity: 2 people, 7.69%
  8. Breast Cancer Metastatic: 2 people, 7.69%
  9. Breast Cancer Female: 2 people, 7.69%
  10. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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Related studies:

Effectiveness of, side effects of, and alternative drugs to the 2 drugs:

Browse all drug interactions of Epinephrine and Xgeva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Epinephrine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all side effects of Xgeva:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Epinephrine and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all interactions between Xgeva and drugs from A to Z:

a b c d e f g h i j k l m n o p q r s t u v w x y z

How the study uses the data?

The study uses data from the FDA. It is based on epinephrine and denosumab (the active ingredients of Epinephrine and Xgeva, respectively), and Epinephrine and Xgeva (the brand names). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.



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