Epipen and Adapalene drug interactions - a phase IV clinical study of FDA data

Summary:

Drug interactions are reported among people who take Epipen (epinephrine) and Adapalene (adapalene). Common drug interactions include skin burning sensation among females and erythema among males.

The phase IV clinical study analyzes what interactions people have when they take Epipen and Adapalene. It is created by eHealthMe based on reports of 26 people who take the same drugs from the FDA, and is updated regularly.

What is Epipen?

Epipen has active ingredients of epinephrine. It is often used in anaphylaxis. eHealthMe is studying from 23,760 Epipen users. Check the latest studies of Epipen.

What is Adapalene?

Adapalene has active ingredients of adapalene. It is often used in acne. eHealthMe is studying from 174,662 Adapalene users. Check the latest studies of Adapalene.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

26 people who take Epipen and Adapalene together, and have interactions are studied.

What are the common drug interactions of Epipen and Adapalene, by gender? *:

female:

Skin burning sensation
Erythema (redness of the skin)
Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)
Dry skin
Overdose
Pain of skin
Rash
Skin atrophy (wasting of skin)

male:

Erythema (redness of the skin)
Hypersensitivity
Urticaria (rash of round, red welts on the skin that itch intensely)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Dyspnoea (difficult or laboured respiration)
Rash
Rash erythematous (redness of the skin)
Swelling face
Swollen tongue (swelling of tongue)
Throat tightness

What are the common drug interactions of Epipen and Adapalene, by age (0-1 to 60+)? *:

0-1:

n/a

2-9:

n/a

10-19:

Erythema (redness of the skin)
Skin burning sensation
Dry skin
Hypersensitivity
Rash
Urticaria (rash of round, red welts on the skin that itch intensely)
Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure)
Dyspnoea (difficult or laboured respiration)
Overdose
Rash erythematous (redness of the skin)

20-29:

Erythema (redness of the skin)
Overdose
Pain of skin
Skin burning sensation
Skin exfoliation (removal of the oldest dead skin cells)
Swelling face
Urticaria (rash of round, red welts on the skin that itch intensely)

30-39:

Skin discolouration (change of skin colour)
Skin hyperpigmentation (disorders affect the colour of your skin)
Skin irritation
Skin swelling
Swelling face
Skin burning sensation
Erythema (redness of the skin)
Eye irritation
Eye swelling
Hypersensitivity

40-49:

n/a

50-59:

n/a

60+:

Chronic kidney disease
Nephrogenic anaemia (anaemia due to kidney disease)
Renal failure (kidney dysfunction)

What are the existing conditions these people have? *

Hypersensitivity: 5 people, 19.23%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 2 people, 7.69%
Food Allergy: 2 people, 7.69%
Arthropod Sting (arthropod bite): 2 people, 7.69%

* Approximation only. Some reports may have incomplete information.

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